1. RSV: RESPIRATORY SYNCYTIAL VIRUS Barbara Woodall

2. BACKGROUND  Discovered in 1956  Childhood illnesses  Causes bronchioltitis & pneumonia  Age 2 ("Respiratory syncytial virus," 2014)

3. BACKGROUND  Family: Paramyxovirida  Subfamily: Pneumovirinae  An enveloped RNA virus  Strains A and B ("Respiratory syncytial virus," 2014) 1

4. TRANSMISSION  Water droplets  Indirect contact  Spreads rapidly among children  Contagious even after 1-3 weeks (“rsvprotection,” 2013)

5. PREVENTION

6.  Hand washing  Keeps hands away from face  Avoid contact with people who are sick  Cover coughs and sneezes  Clean and disinfect surfaces  Stay home when sick ("Respiratory syncytial virus," 2014)

7.  Warm water  Soap  Remove jewelry  Wash for twenty seconds HAND WASHING 2

8. SYMPTOMS  Illness 4-6 days after exposure  Runny nose and decrease in appetite (2-8 days)  Coughing, sneezing and fever (1-3 days after)  Infants: Irritability Decreased activity and breathing ("Respiratory syncytial virus," 2014)

9. RED ALERT SIGNS  Non stop coughing or wheezing  Fast or troubled breathing  Fever > 100  Bluish color around mouth or fingernails  Spread-out nostrils and/or caved-in chest  Gasping for breath (“rsvprotection,” 2013)

10.  Antigen Detection Test  Suplement Antigen Testing with cell culture  RT-PCR assay ("Respiratory syncytial virus," 2014) DIAGNOSING 3

11. TREATMENT  Recovery in 1-2 weeks  May cause Sever lung infections  Some infants may require hospitalization ("Respiratory syncytial virus," 2014)

12. HIGH RISK 4

13.  Infants under 6 weeks  Born before 35 weeks  Chronic lung disease  Congenital heart disease  Weekend immune systems ( Anekwe) (“rsvprotection,” 2013)

14. STATISTICS  4,500 deaths a year in the US Infants 2-6 months  Life-threatening pneumonia Easily diagnosed as influenza  About 1% of children will require hospitalization  Between 25-40 out of 100 young children show sings of pneumonia or bronchiolitis ("Respiratory syncytial virus," 2014) (Tortora, Case & Case, 2010)

15. PREVALENCE  Varies by location (RSVprotection)  Time and severity vary from year to year  Usually occurs during late fall, winter and early spring ("Respiratory syncytial virus," 2014)

16. PREVALENCE 5

17. NEW DEVELOPMENTS  Immune globulin product has been approved  Protective vaccines being clinically tested  Sever symptoms helped by aerosol  Humanized monoclonal antibody (Tortora, Case & Case, 2010)

18. NEW DEVELOPMENTS  Respiratory illness in older adults ("Respiratory syncytial virus," 2014)  Palivizumab for high risk children (Anekwe, 2009)  Antivirals with anti-inflammatory therapies ("Respiratory syncytial virus," 2010)  New imaging technique to study RSV living cells (Toon, 2013)

19. SUPER-RESOLUTION OPTICAL IMAGE 6

20. PLACES DOING RESEARCH  Arctic Investigation Program ("Respiratory syncytial virus," 2014) immunity  National Institute of Allergy and Infectious Diseases ("Respiratory syncytial virus," 2010) Immunity  National Institute of General Medical Sciences (Toon, 2013) How it enters How it Replicates How many genomes inserted into hosts

21. WORKS CITED  Anekwe, Lilian. Government considers immunizing children against RSV. (2009, January 14). Retrieved form http://www.pulsetoday.co.uk/government-considers-immunising-children-against-rsv/10995958.article#.UzXevNytg2w http://www.pulsetoday.co.uk/government-considers-immunising-children-against-rsv/10995958.article#.UzXevNytg2w  Paving the way for respiratory syncytial virus. ( 2013, September). Retrieved form http://www.path.org/publications/files/VAC_rsv_fs.pdf http://www.path.org/publications/files/VAC_rsv_fs.pdf  Rsv protection. (2013). Retrieved from https://www.rsvprotection.com/index.htmlhttps://www.rsvprotection.com/index.html  Respiratory syncytial virus. (2014, April 01). Retrieved from http://www.cdc.gov/rsv/http://www.cdc.gov/rsv/  Respiratory Syncytial Virus. (2010, March 15) Retrieved from http://www.niaid.nih.gov/topics/rsv/research/pages/researchrole.aspx http://www.niaid.nih.gov/topics/rsv/research/pages/researchrole.aspx  Toon, John. (2013, December 30). Imaging Technology Could Unlock Mysteries of a Childhood Disease. Retrieved form http://www.news.gatech.edu/2013/12/29/imaging-technology-could-unlock-mysteries-childhood-disease http://www.news.gatech.edu/2013/12/29/imaging-technology-could-unlock-mysteries-childhood-disease  Tortora, G., Case, C., & Case, C. (2010). Microbiology: An introduction. (10th ed., p. 692). San Francisco: Pearson Education Inc

22. PICTURE CITED  Respiratory syncytial virus RSV. Retrieved fromhttp://www.bode-science-center.com/center/relevant- pathogens-from-a-z/respiratory-syncytial-virus.htmlhttp://www.bode-science-center.com/center/relevant- pathogens-from-a-z/respiratory-syncytial-virus.html  Sucher, Peggy. Hand Washing – The #1 Deterrent to the Spread of Contaminants. (2011, November 7) Retrieved form http://tattooroadtrip.com/wp-content/uploads/2011/10/Handwashing-3.jpghttp://tattooroadtrip.com/wp-content/uploads/2011/10/Handwashing-3.jpg  Respiratory Syncytial Virus. Retrieved from http://www.corisbio.com/Products/Human- Field/RSV.phphttp://www.corisbio.com/Products/Human- Field/RSV.php  Rsv protection. (2013). Retrieved from https://www.rsvprotection.com/index.htmlhttps://www.rsvprotection.com/index.html  Respiratory syncytial virus. (2014, April 01). Retrieved from http://www.cdc.gov/rsv/http://www.cdc.gov/rsv/  Toon, John. (2013, December 30). Imaging Technology Could Unlock Mysteries of a Childhood Disease. Retrieved formhttp://www.news.gatech.edu/2013/12/29/imaging-technology-could-unlock-mysteries- childhood-diseasehttp://www.news.gatech.edu/2013/12/29/imaging-technology-could-unlock-mysteries- childhood-disease

23. REVIEW QUESTIONS 1. Which state/region has the longest duration of RSV season? A.Florida B.Region 7 C.Region 3 2. By what age have most children has RSV? A.6 months B.1 C.2 3. How long are you contagious after contracting the virus A.1-2 days B.1-3 weeks C.1 month