1. SC430 Molecular & Cell Biology Welcome SC430 -01 to our 1st Seminar Professor = Dr Hall-Pogar I am available at AIM: Kaplanhallpogar before and after seminar for any additional questions We will begin promptly at 9:00PM est

2. Seminar 1 Objectives Overview of the Course Primordial Soup --> Jurassic Park

3. course information Term: 1105C Dates: November 9th, 2011 – January 24, 2011 Holiday: Thanksgiving, Nov 24-27th Christmas, Dec 24 - Textbook: The Cell: A Molecular Approach, Fifth Edition

4. Course Structure Seminars, discussion boards, & projects are graded each unit Mid-term & Final Exam

5. Helpful Hints Check email Read weekly announcements Reference all facts in DB’s and projects Use APA style Communicate with me!

6. ORIGIN AND EVOLUTION OF CELLS The First Cell: All present-day cells, both prokaryotes and eukaryotes, are descended from a single ancestor The first cell is thought to have arisen at least 3.8 billion years ago As a result of enclosure of self-replicating RNA in a phospholipid membrane

7. Stanley Miller & Harold Urey Experiments Elegant set of experiments Under conditions believed to be similar to those found on the early Earth Organic molecules could spontaneously arise Providing the building blocks for the first living organisms Raw materials + Energy ⇒ Life molecules

8. DNA or RNA? RNA World Hypothesis Hypothesis proposes that life based on RNA pre-dates the current world of life based on DNA, RNA and proteins RNA is able both to store genetic information, like DNA, and to catalyze chemical reactions, like an enzyme. DNA is thought to have taken over the role of data storage due to its increased stability Proteins with a greater variety of monomers (amino acids), replaced RNA's role in specialized biocatalysis

9. Jurassic Park? Developmental biologists at the University of Wisconsin observed mutant chickens that had beaks contained structures resembling teeth(2005) Experimentally able to trigger the formation of teeth in a normal chicken by turning on a particular gene Question: Will scientists ever be able to resurrect the dinosaur? Read more: http://www.dailymail.co.uk/sciencetech/article- 1026340/Jurassic-Park-comes-true-How-scientists-bringing- dinosaurs-life-help-humble-chicken.html#ixzz1dVB9L9Hxhttp://www.dailymail.co.uk/sciencetech/article- 1026340/Jurassic-Park-comes-true-How-scientists-bringing- dinosaurs-life-help-humble-chicken.html#ixzz1dVB9L9Hx

10. Origin of Eukaryotes Eukaryotic cells are thought to have evolved from symbiotic associations of prokaryotes The genome of eukaryotes may have arisen from a fusion of eubacterial and archaebacterial genomes

11. Present-Day Prokaryotes Divided into two groups Archaebacteria and the eubacteria

12. Eukaryotic Cells Larger and more complex than prokaryotic cells Contain a nucleus, cytoplasmic organelles, and a cytoskeleton

13. Evolution of Metabolism Earliest reactions for the generation of metabolic energy were a form of anaerobic glycolysis Photosynthesis then evolved, followed by oxidative metabolism

14. Development of Multicellular Organisms The simplest eukaryotes are unicellular organisms Such as yeasts and amoebas Multicellular organisms evolved from associations between unicellular eukaryotes Division of labor led to the development of the many kinds of specialized cells that make up present-day plants and animals