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Cutaneous Malignant Melanoma Surveillance, Epidemiology, and End Results (SEER) Program (www.seer.cancer.gov ) M F Fears TR, Tucker MA. J Natl Cancer Inst.

Published byQuentin Roland Gallagher Modified over 9 years ago

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Presentation on theme: "Cutaneous Malignant Melanoma Surveillance, Epidemiology, and End Results (SEER) Program (www.seer.cancer.gov ) M F Fears TR, Tucker MA. J Natl Cancer Inst."— Presentation transcript:

1 Cutaneous Malignant Melanoma Surveillance, Epidemiology, and End Results (SEER) Program (www.seer.cancer.gov ) M F Fears TR, Tucker MA. J Natl Cancer Inst. 2005, 97:1789-90 Frances Noonan, EOH,SPHHSdrmfpn@gwumc.edu 202-994-3970

2 Photobiology of melanoma Wavelengths responsible-UVA, UVB or both ?Wavelengths responsible-UVA, UVB or both ? Critical UV-induced molecular alterations to melanocytes ?Critical UV-induced molecular alterations to melanocytes ? Pigment- protective or promotional ?Pigment- protective or promotional ? Role of the immune system – UV effects on immunity?Role of the immune system – UV effects on immunity? Frances Noonan, EOH,SPHHS

3 Melanoma induced by UV irradiation of HGF/SF transgenic mice Noonan et al., Nature, 2001; Recio et al, Cancer Res, 2002; in prep Frances Noonan, EOH,SPHHS

4 Functional Mc1r is necessary for UV-induced melanoma YELLOW BLACK Frances Noonan, EOH,SPHHS

5 Neonatal host UV irradiation promotes melanoma outgrowth Heather Poetschke-Klug et al Frances Noonan, EOH,SPHHS

6 Acknowledgements Photobiology lab, GWUMCPhotobiology lab, GWUMC –Ed De Fabo –J. Bahn; research assistants and students –Agnieszka Wolnicka-Glubisz; Stephanie Constant; Jesse Damsker Glenn Merlino, NCI/NIHGlenn Merlino, NCI/NIH Miriam Anver, SAIC, FCRFMiriam Anver, SAIC, FCRF Funding- NCI/NIH; Elaine Snyder Cancer Research Fund, GWUMCFunding- NCI/NIH; Elaine Snyder Cancer Research Fund, GWUMC Frances Noonan, EOH,SPHHS

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