1. The Muscular System Chapter 6

2. Skeletal Muscle Bundles of striped muscle cells Attaches to bone Often works in opposition biceps triceps

3. Tendons Attach Muscle to Bone muscle tendon bursae synovial cavity

4. Human Skeletal Muscles TRICEPS BRACHII PECTORALIS MAJOR SERRATUS ANTERIOR EXTERNAL OBLIQUE RECTUS ABDOMINUS ADDUCTOR LONGUS SARTORIUS QUADRICEPS FEMORIS TIBIALIS ANTERIOR BICEPS BRACHII DELTOID TRAPEZIUS LATISSIMUS DORSI GLUTEUS MAXIMUS BICEPS FEMORIS GASTROCNEMIUS

5. Skeletal Muscle Structure A muscle is made up of muscle cells A muscle fiber is a single muscle cell Each fiber contains many myofibrils myofibril

6. Sarcomere Z band sarcomere A myofibril is made up of thick and thin filaments arranged in sarcomeres

7. Muscle Microfilaments Thin filaments Like two strands of pearls twisted together Pearls are actin Other proteins in grooves in filament Thick filaments Composed of myosin Each myosin molecule has tail and a double head

8. Sliding-Filament Model Myosin heads attach to actin filaments Myosin heads tilt toward the sarcomere center, pulling actin with them

9. Sliding-Filament Model Sarcomere shortens because the actin filaments are pulled inward, toward the sarcomere center

10. Contraction Requires Energy Muscle cells require huge amounts of ATP energy to power contraction The cells have only a very small store of ATP Three pathways supply ATP to power muscle contraction

11. ATP for Contraction Pathway 1 DEPHOSPHORYLATION CREATINE PHOSPHATE Pathway 2 AEROBIC RESPIRATION Pathway 3 GLYCOLYSIS ALONE creatine oxygen glucose from bloodstream and from glycogen break down in cells ADP + P i Relaxation Contraction

12. Nervous System Controls Contraction Signals from nervous system travel along spinal cord, down a motor neuron Endings of motor neuron synapse on a muscle cell at a neuromuscular junction

13. Role of Calcium in Contraction T tubules in the sarcoplasmic reticulum relay signal Calcium ions are released

14. Troponin and Tropomyosin Lie in groove in actin filament When muscle is relaxed, tropomyosin blocks myosin binding site When troponin binds calcium ions, it changes shape and moves tropomyosin Cross-bridge formation and contraction can now proceed

15. Muscle Tension Is mechanical force a contracting muscle exerts on an object For a muscle to shorten, muscle tension must exceed the load that opposes it The load may be the weight of an object or gravity’s pull on the muscle

16. Two Main Types of Contraction Isotonic contraction –Muscle visibly shortens; moves a load –Tension remains constant as the muscle changes length Isometric contraction –Muscle does not change length –Tension is insufficient to move load

17. Motor Unit One neuron and all the muscle cells that form junctions with its endings When a motor neuron is stimulated, all the muscle cells it supplies are activated to contract simultaneously Each muscle consists of many motor units

18. Twitches and Tetanus peak relaxation stimulus contraction starts time number of stimuli per second tetanic contraction repeated stimulation twitch

19. Two Types of Skeletal Muscle Slow, or red, muscle –Many capillaries, high myoglobin –Contracts fairly slowly –Can sustain contraction Fast, or white, muscle –Fewer capillaries, less myoglobin –Contracts quickly –Cannot sustain contraction

20. Muscle Fatigue An inability to maintain muscle tension Occurs after a period of tetanic contraction Different types of muscle show different fatigue patterns