1. ACCELERATING CLINICAL AND TRANSLATIONAL RESEARCH www.indianactsi.org Supercores – Genomics & Metabolomics/Proteomics Indiana CTSI – Purdue Retreat MONDAY, April 21, 2014

2. ACCELERATING CLINICAL AND TRANSLATIONAL RESEARCH www.indianactsi.org Objectives Review how CTSI facilitates core use today Propose how “Supercores” can enhance research at CTSI member institutions Discuss challenges

3. ACCELERATING CLINICAL AND TRANSLATIONAL RESEARCH www.indianactsi.org Access Technology Program ATP Infrastructure HUB/Help Desk Core Pilot Grants Investigation Agents Program Facilitation Sample Storage Facility Clinical Translational Lab Quality Core Oversight KSOB Business Management ATP Quality Program Cores Management

4. ACCELERATING CLINICAL AND TRANSLATIONAL RESEARCH www.indianactsi.org ATP and Cores Be a resource for investigators requiring core services –Help Desk and Liaisons –HUB Improve quality of core services

5. ACCELERATING CLINICAL AND TRANSLATIONAL RESEARCH www.indianactsi.org ATP People ATP Ken Cornetta Lilith Reeves Jenna York Purdue Tommy Sors ND Melanie DeFord IUSM Jeanette McClintick IUSM Todd Skaar IUB Yvonne Lai

6. ACCELERATING CLINICAL AND TRANSLATIONAL RESEARCH www.indianactsi.org 70+ Cores and Resources https://www.indianactsi.org/servicecores

7. ACCELERATING CLINICAL AND TRANSLATIONAL RESEARCH www.indianactsi.org Comparative Options

8. ACCELERATING CLINICAL AND TRANSLATIONAL RESEARCH www.indianactsi.org

9. ACCELERATING CLINICAL AND TRANSLATIONAL RESEARCH www.indianactsi.org 46 CTSI Approved Cores –Initial Review –Annual reassessment Establish Policies User satisfaction Oversight committee Approved prices by the University

10. ACCELERATING CLINICAL AND TRANSLATIONAL RESEARCH www.indianactsi.org Supercore Concept Investigators identifies Need Need assessed: Equipment Expertise Turnaround Purdue Notre Dame IUB IUSM

11. ACCELERATING CLINICAL AND TRANSLATIONAL RESEARCH www.indianactsi.org Supercore Advantages Core –Provide more consistency of activity/ ? More activity –Collaboration / sharing of knowledge –Access to new technologies Investigator –Access to different technologies –More timely results Institution –Resource allocation savings –Integration with other cores –Negotiating vendor costs

12. ACCELERATING CLINICAL AND TRANSLATIONAL RESEARCH www.indianactsi.org Challenges A21 Circular Regulation applies to billing for core services on federally funded grants Requirement related to accepting indirects on grant Charge must not exceed true cost of delivering service

13. ACCELERATING CLINICAL AND TRANSLATIONAL RESEARCH www.indianactsi.org A21 Challenge to Cores Don’t meet quota you run at a loss Exceed quota have to decrease prices No mark-up = no reserves No funds for development No funds to replace equipment Cores can’t survive on this model

14. ACCELERATING CLINICAL AND TRANSLATIONAL RESEARCH www.indianactsi.org Maintaining Core in the Black Institutional support –Provide base funding to allow development –Replace equipment and handle unexpected costs –Allow to subsidize costs so price to investigator may be less than actual cost of service Find non-federal sources of support –Commercial work

15. ACCELERATING CLINICAL AND TRANSLATIONAL RESEARCH www.indianactsi.org CTSI Challenges to Supercores Prices differ among the 4 campuses for similar services Difference reflects level of institutional support for a core Inter-institutional prices need to balance investment by home institution and ease of use

16. ACCELERATING CLINICAL AND TRANSLATIONAL RESEARCH www.indianactsi.org Next-Gen Sequencing Cores in the CTSI IUSM –SOLID 5500xl; Ion Torrent, Ion PGM Notre Dame –Illumina MiSeq IUB –Illumina MiSeq Purdue –Illumina HiSeq2500

17. ACCELERATING CLINICAL AND TRANSLATIONAL RESEARCH www.indianactsi.org Sequencing Questionnaire WorkloadToo variable, not enough Too variable Too busy * Not enough BioinformaticsOutside core50:50 core and outside Both inside and outside core Outside core Sample prepCore Core and investigators Core Outsource of samples 0% 65%0%

18. ACCELERATING CLINICAL AND TRANSLATIONAL RESEARCH www.indianactsi.org Sequencing Questionnaire Users Own University75%80%85%84% Other CTSI25%10% 1.5% Other Academic0% 10%5%14% Experience of Users Very10%20%50%25% Moderate15%30%25%45% Inexperienced75%50%25%30%

19. ACCELERATING CLINICAL AND TRANSLATIONAL RESEARCH www.indianactsi.org Today’s Workshop Hearing from the research community Broader discussion of –Advantages –Challenges Expand on the discussion