1. Carboxylic Acids Derivatives other than Ester Nanoplasmonic Research Group Organic Chemistry Chapter 10 Part II

2. Activated Acyl Compounds - Focus on leaving group - Acyl Halides Carboxylic acids with thionyl chloride or phosphorus pentachloride Acid Anhydrides Carbonylation of methylacetate or dehydration of carboxylic acids

3. Acyl halides can react with.. Water to form a carboxylic acid Alcohol to form an ester Amine to form an amide

4. Acid anhydrides can react with.. Water to form a carboxylic acid Alcohol to form an ester Amine to form an amide “The point is acid anhydride is more reactive than ester, but less reactive than acyl halide toward nucleophile”

5. The least reactive carboxylic acid derivative - Amide - The reaction of a carboxylic acid with an amine Planar geometry!!: rotation around the C-N bond is restricted due to resonance High boiling point

6. The Claisen Condensation (I) Carbon-carbon bond forming reaction that occurs between two esters or one ester and another carbonyl compound in the presence of a strong base At least one of the reagents must be enolizable The base used must not interfere with the reaction (nonnucleophilic!!!!)

7. The Claisen Condensation (II)

8. Summary (Reaction of Acid Derivatives)

9. The Claisen Condensation (II)