1. The Plasma Membrane – a Phospholipid Bilayer

2. Components of Plasma Membrane Lipids Proteins 1) Phospholipids 2) Cholesterol 3) Glycolipds 1) Peripheral (Associated) 2) Integral (Membrane Spanning) 3) Glycoproteins ~50% (75%) (20%) (5%)

3. Roles of the Plasma Membrane

4. Protein Transporters 1) Channels 2) Carriers a) open b) gated* * triggered to open

5. Cell Transport Mechanisms Passive Active 1) Diffusion 2) Facilitated Diffusion 3) Filtration 1) Primary (Direct) 2) Secondary (Indirect) 3) Vesicular

6. Diffusion

7. Rate of Diffusion

8. Primary Active Transport: The Na + /K + Pump Antiport

9. The Na + /K + Pump

10. Secondary Active (Indirect): e.g., Na + /Glucose transporter Symport

11. The Na + /glucose Symport

14. Transportation of the usual suspects

15. Endocytosis and Exocytosis

16. Transcytosis – e.g., inside Vesicle.

17. Tissue Compartment Volumes

18. 67% is intracellular About 60-70% of body weight is water 33% is extracellular –8% plasma –25% interstitial Distribution of Water and Solutes in the Body Compartments Inside cells

19. Transcapillary Fluid Dynamics HP = Hydrostatic Pressure (force of a fluid on walls of its container) ↑HP ↓HP ↑↑ COP ↓↓ COP ↑↑ COP COP = Colloid Osmotic Pressure (force generated by proteins in solution) ↓HP Cells (ICF) (interstitium) arterial end venous end (plasma in capillary) Filtration Reabsorption = fluid movement