1. Plasma Membrane Structure and Role in Cellular Transport

2. Membrane Structure Phospholipid bilayer Protein Fluid Mosaic Model Hydrophobic Hydrophylic

3. Membrane Proteins Transport Enzyme Signal transduction Cell recognition Cell joining Attachment to cytoskeleton and ECM

4. External to Plasma Membrane Prokaryote –Cell wall –Peptidoglycan Plant Cell –Cell wall –Cellulose Animal Cell –Extra Cellular Matrix

5. Extracellular Matrix Integrin Fibronectin Collagen Proteoglycan Microfilaments

6. Cell Junctions Tight Junction –Seal –actin Adherens junction –Cytoskeleton to ECM –Actin –integrin Desmosome –Rivet like –keratin

7. Transport Passive –Diffusion –Osmosis –Facilitated diffusion Active –Pump Bulk –Endocytosis –exocytosis

8. Diffusion Solute moves Net movement down a concentration gradient Endpoint equilibrium Oxygen Carbon dioxide

9. Osmosis Solvent moves Requires a semi permeable membrane Concentration gradient driven Endpoint equilibrium

10. Facilitated Diffusion Protein required Concentration gradient driven Net movement down the concentration gradient Endpoint equilibrium

11. Active Transport Requires membrane protein Requires ATP Pump Moves substances against a concentration gradient Ions

12. Bulk Transport Very large substances Requires use of vesicles Fusion with plasma membrane Endocytosis Exocytosis Phagocytosis pinocytosis

13. Videos http://www.youtube.com/watch?v=ULR79T iUj80http://www.youtube.com/watch?v=ULR79T iUj80 http://www.youtube.com/watch?v=4gLtk8Y c1Zc&feature=relatedhttp://www.youtube.com/watch?v=4gLtk8Y c1Zc&feature=related http://www.youtube.com/watch?v=W6rnhi MxtKUhttp://www.youtube.com/watch?v=W6rnhi MxtKU