1. Wearable sensors: MJFF's wearable sensor platform to quantify PD in clinical trials and across patient populations
Ken Kubota
Director of Data Science at the Michael J Fox Foundation
Shahar Shpigelman
Intel Big Data Analytics

2. MJFF is the world’s largest nonprofit funder of pd research
Our Mission
To accelerate the development of improved therapies, and ultimately a cure, for people living with Parkinson’s disease today.
$500 million in research funded to date
$70 million in research grants funded in 2014
1,500 projects funded to date
500 active grants in current portfolio
30% of funded project are outside of the U.S.
Fund academics, biotechs and pharma

3. The paucity of “real” clinical measures, cost of trials and the ability to scale.
Need for more sensitive diverse measures
Detect natural progression <1yr
Continuous measures in the real world
AVERAGE TRIAL SIZE
< 100
PATIENTS
COST OF TRIALS
are in the scales of $M
VERY SMALL
number of patients contribute to research

4. History
Big data analytics
IOT

5. important nexus in technology
“Biosensing wearable products being developed today could not have existed just 4 years ago”
Bluetooth Low Energy radio, iPhone 4s was the 1st to implement
Wireless Qi charging coil standard
MEMS accelerometers price drops 5x

6. Program to Implement Wearable Sensor Technologies for PD
Aims:
Speed trials while reducing cost
Identify new phenotypes of Parkinson’s disease
Improve the quality of care of Parkinson’s disease patients

7. The System MANAGE THE DISEASE USING DATA Clinically Meaningful Data
RESEARCHER
MANAGE THE DISEASE USING DATA
Data for Analysis
Analytics
BIG DATA CLOUD
Patient and CLINICIAN
Clinically Meaningful Data
INSIGHT / VALUE

8. Our data infrastructure
Historical trials
Historical trials
Patient stratification (unsupervised analysis)
Disease progression models (machine learning)
Report sharing
Curation
ETL tool
Patient
de-identification
Time series data model
Either use real demo or show the next 2 slides
Initial phase of portal

9. Key learning

16. Iterative Design and Discovery

17. Clinical Trials CLINICAL TRIALS Create and Validate
DATA GATHERING TRIAL
CLINICAL TRIALS
L-DOPA RESPONSE TRIAL
Create and Validate
Algorithm & Measures
SCRIPPS TREMOR TRIAL

18. Using Big data analytics
Population Trials
REAL PD
POPULATION STUDY
FOX INSIGHT WEAR
Generate insights
Using Big data analytics

19. The road ahead This Summer:
Integration of mPower as our pilot iPhone offering
This Winter:
Integration of features across both Android and IOS as our cross platform offering

20. Call to action Let’s free the data
Write broad consent forms that allow data to be shared openly
Let the patient own the data
Put research in the hands of the patient
Come to us with your ideas and proposals

21. Q&A