1. Random walk through NIH grants Yi Wang @ Cornell BME Surgery retreat 08

2. Why do you want to do NIH grant? Money, more money Everyone is doing it May be the best review process –Transparent/fair, iterative …

3. All you want to know are readily available at your finger tips! www.nih.gov http://grants.nih.gov/grants/oer.htm

4. NIH: Myths, realities… http://grants.nih.gov/grants/peer/prac/prac_may_200 6/zerhouni_crossroads.ppt#407,1,Slide 1 55% basic research; 45% applied research; 5% other 92% unsolicited (investigator initiated); 8% solicited 20% success rate

5. Reviewers’ point of view Significance Approach Innovation Investigators Environment

6. Anatomy of NIH grant application Cover letter –Study section, funding institute, science area Research plan –Specific aims, Background, Preliminary data, Research design Additional materials Work on revision

7. How have I done it? Commit myself to hard work –Idea, preliminary studies, grant writing Fight with English –A stupid farmer moves a mountain –Focus on science; writing adds clarity Keep work on my idea until success –No pause after submission, more data for revision

8. An example: early sepsis diagnosis Idea –septic macrophage can be detected by MRI with nanoparticles before organ failure Seek grant got poor review –mice and patient exploration, fishing… –biological pathway? What to do –approach is valid and valuable –no money? work >> 40 hrs/wk (<168 hrs/wk)