1. Case 2 M-36,Erythematous rash on abdomen H/o Alport’s syndrome Failed renal transplant on hemodialysis

2. Clinical presentation  Alport’s syndrome diagnosed in 1973 – progressed to ESRF  Cadaveric renal transplant in 1992  CAPD commenced in 2005  Peritonitis and subacute bowel obstruction necessitated a  2 nd Cadaveric renal transplant in 2010  PD port removed in 2011

3. Presenting Symptoms  Generalised abdominal pain  Weight loss  20x15cm erythema in periumbilical area  All other investigations negative  No response to I/V antibiotics  Biopsy performed

10. REACTIVE ANGIOENDOTHELIOMATOSIS

11. RAE  Clinically-  Erythematous violaceous papules  Macules, nodules  Cellulitis like areas  Seen in abdominal areas, thighs and legs  Also seen in other sites

12. RAE  Represents a hypersensitivity reaction  Different stimuli- cryoproteins and microorganisms  Vessel occlusion—hypoxaemia— endothelial proliferation  Reported in association with bacterial endocarditis and other renal diseases.