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Autosomal Dominance Inheritance What’s an Autosome? Autosome: Non sex chromosome – Ex: Autosomal disorders: gene for the disease is found on chromosomes.

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Presentation on theme: "Autosomal Dominance Inheritance What’s an Autosome? Autosome: Non sex chromosome – Ex: Autosomal disorders: gene for the disease is found on chromosomes."— Presentation transcript:

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2 Autosomal Dominance Inheritance

3 What’s an Autosome? Autosome: Non sex chromosome – Ex: Autosomal disorders: gene for the disease is found on chromosomes 1-22 Autosomal Recessive Inheritance – Must inherit two copies of the disorder to be affected – Healthy is dominant (HH or Hh) – Disease is recessive (hh) – Ex: Cystic fibrosis, PKU, Albinism, Sickle cell anemia Autosomal Dominance Inheritance – Only need to inherit one copy of the disorder to be affected – Disease is dominant (HH or Hh) – Healthy is recessive (hh) – Ex: Familial hypercholesterolemia (also called FH), Huntington’s disease, Neurofibromatosis

4 Autosomal Dominance Inheritance Disease is dominant (HH or Hh) – Homozygous dominant: early death and don’t survive to reproduce – Heterozygous live into adulthood Healthy is recessive (hh) ex: Paul has familial hypercholesterolemia and Stacy is healthy. The two have 3 children. After testing, the middle child is the only healthy child. Key H = FH disease h= healthy disease healthy PaulStacy Hh hh

5 Autosomal Dominance Inheritance Huntington’s disease is a dominant disorder found on chromosome 4. Betty and Marcus met at a support clinic they have been attending to help them cope with the knowledge of their illness with Huntington’s disease. They would like to know the risk of having a healthy child, now that Betty is pregnant. Key H = Huntington’s disease h = healthy Disease (severe) disease diseasehealthy ? MarcusBetty Hh

6 Woody Guthrie: This Land is Made for You and Me

7 Video about Huntington's disease Autosomal dominant disorder Brain cells start to die in late 30’s Causes uncontrollable muscle jerking Death usually in 40’s-50’s No treatments Click if YouTube video doesn’t work


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