1. Genetic Mutations Shar – Pei Dog

2. Shar-Pei

3. Objective  Explore how genes cause phenotypes in Shar-Pei dogs.

4. Instructions: 1. Read the New York Times Article: Canine Genetic Wrinkle Has Potential for Humans by Sindya N Bhanoo 2. Copy and answer the questions on the next slide 3. Discussion, notes and conclusion

5. Questions 1. What are the two phenotypes? 2. What substance causes the wrinkles? 3. What gene causes that substance? 4. How would the frequent fever be connected genetically to the wrinkles? Hint: Part C, Can You Sort it Out? page 435 5. What is the connection to humans?

6. Phenotype variations

7. Discuss photo  Which dog will be most likely have the fever trait?  Which dog will be least likely to have the fever trait?

8. Conclusion  Describe the connection between the shar-pei dog’s genotype and phenotype.