1. Chapter 2 The Central Dogma: Exploring Genetic Disease

2. Figure 2.1: “Sickled” red blood cells © Eye of Science/Photo Researchers, Inc.

3. Figure 2.2: The hemoglobin molecule

4. Figure 2.3: An individual has two copies of each gene: the same (homozygous) or different (heterozygous)

5. Figure 2.4: Four possible outcomes for the child of two carriers of the sickle-cell trait. W=wild-type allele; S=sickle-cell allele

6. Figure 2.5: A DNA molecule is made up of two strands of nucleotides

7. Figure 2.6: Synthesis of RNA, a single-stranded molecule complementary to one of the two DNA strands

8. Figure 2.T1: The Genetic Code

9. Figure 2.7: Diagram showing how a single gene encoded in DNA is transcribed and translated to produce a protein

10. Figure 2.8: The human HBB gene in FASTA format

11. Figure 2.9: A vest designed to improve lung function for cystic fibrosis patients © 2008 Hill-Rom Services, Inc., Reprinted with Permission-All rights Reserved.

12. Figure 2.10: Schematic diagram showing the structure of the CFTR protein that regulates transport of chloride through cell membranes