1. Diabetes- Chapter 43 Revised 11/10

2. Types of Diabetes Type 1 — insulin- dependent diabetes mellitus (IDDM) Insulin produced in insufficient amount Requires insulin Type 2 — non-insulin- dependent diabetes mellitus (NIDDM) Decreased production of insulin or decreased cell sensitivity to insulin May be treated with oral drug and/or insulin

3. Four Pillars of Management of Diabetes Meal planning referred to as medical nutrition therapy Activity and exercise Medication Self monitoring of blood glucose (SMBG)

4. Insulin A hormone produced by the beta cells in the pancreas that acts to maintain blood glucose levels within normal limits

5. Insulin Essential for the use of glucose in cellular metabolism and for proper protein and fat metabolism

6. Insulin Controls the use of glucose, protein, and fat in the body Lowers blood sugar by inhibiting glucose production by the liver

7. Insulin Available as purified extracts from beef and pork pancreas (used infrequently) Synthetic insulins, such a human insulin and insulin analogs; derived from strains of Escherichia coli (recombinant DNA), fewer allergies with this than extracts of beef and pork Activates a process that helps glucose molecules enter the cells Stimulates the liver glycogen synthesis

8. Insulin (Con’t) Used to treat diabetes mellitus and control more severe and complicated forms of type 2 diabetes

9. Insulin Injections Must be injected into the subcutaneous in the legs, arms, stomachs or buttocks. Cannot be taken orally

10. ADMINISTERING INSULIN BY INJECTION Administered with an insulin syringe

11. Insulin Preparations See handout from Introduction to Pharmacology Text, page 546

12. Onset, Peak, and Duration of Action Define onset, peak and duration

13. Insulin Contraindications Contraindicated if patient has hypersensitivity to any ingredient in the product (older preparations made with beef and pork) and if the patient is hypoglycemic

14. Precautions Used cautiously with renal and hepatic impairment and during pregnancy and lactation

15. Interactions See table 49-1 Drugs that Decrease and Increase the Hypoglycemic Effect of Insulin, page 547 Include as nursing considerations

16. Drugs that Decrease the Hypoglycemic Effect of Insulin

17. Drugs that Increase the Hypoglycemic Effect of Insulin

18. MIXING INSULINS Insulins tend to bind and become equilibrated Inject within 5 minutes of mixing Regular which is additive free, is combined with intermediate-acting insulin such as Humulin

19. Mixing Insulins

20. Promoting Optimal Response to Insulin Therapy Will be individualized Expect adjustments when under stress and with any illness, particularly illnesses resulting in nausea and vomiting

21. Examples of Insulin Administration using a Sliding Scale Handout from Morton Hospital (use as an example) Double sided (reverse has how to treat hypoglycemia) Follow agency protocol

22. Preparing Insulin for Administration Current insulin bottle at room temperature, except Lantus which is refrigerated

23. Rotating Injection Sites Rotating sites prevents lipodystrophy (atrophy of subcutaneous fat) Lipodystrophy interferes with absorption of insulin

24. Body Diagram of Appropriate Sites

25. Methods of Administering Insulin Parenteral-subcutaneous or intravenous Insulin Pump Inhalation

26. Insulin Pumps Newer technology. Attempts to mimic the body’s normal pancreatic function. Only regular insulin is used. Needle inserted subcutaneously and left in place for 1-3 days Battery operated. Amount of insulin injected can be adjusted according to blood glucose levels (monitored 4-8 times a day)

27. Inhaled Insulin Food and Drug Administration approved the first noninjectable insulin in a dry inhalation powder in early 2006 (Exubera).

28. Monitoring and Managing Adverse Reactions Must know signs and symptoms of hypoglycemia and hyperglycemia

29. Signs of Hyperglycemia

30. Signs of Hypoglycemia

31. Educating the Patient and Family Review principles of teaching the adult patient Noncompliance may be a problem with some patients (may be related to lack of understanding of disease process or medications or management) Establish a thorough teaching plan for patients newly diagnosed, for patients with changes in treatment plan Include teaching on diet, glucose monitoring, medications, adverse reactions, hygiene, exercise, sick day protocols, medic alert bracelets

32. Nursing Diagnoses Anxiety and Fear Impaired Adjustment, Coping, and Altered Health Maintenance Acute confusion related to hypoglycemic reaction

33. Oral Drugs Sulfonylureas Biguanides Alpha-glucosidase inhibitors Meglitinides Thiazolidinediones Hormone Mimetic Agents –many diffferent actions to help lower blood sugar levels, see page 424; Januvia, Byetta, Symlin See Summary of Drugs- pages 420-421 Sometimes oral antidiabetic drugs are used in combinations

34. Sulfonylureas Examples — tolbutamide (Orinase), glipizide (Glucotrol), glyburide (Diabeta, Micronase), glimepiride (Amaryl) Act to lower blood glucose by stimulating the beta cell to release insulin Adverse Reactions — Nursing considerations: Secondary failure may occur (may lose effectiveness, may prescribe another sulfonylureas or add another oral antidiabetic drug such as metformin

35. Biguanides Example—metformin (Glucophage) Action—reduces hepatic glucose production and increases insulin sensitivity to muscle and fat cells Adverse Reactions— Rare SE: lactic acidosis with kidney failure Nursing implications; give with meals. Glucophage XR given once daily with evening meal. Glucophage must be stopped 48 hours before and after radiology studies that use iodine

36. Alpha-Glucosidase Inhibitors Examples—acarbose, miglitol Action—lower blood sugar by delaying carbohydrate digestion and absorption Adverse Reactions— Nursing considerations:

37. Meglitinides Examples—nateglinide (Starlix), repaglinide (Prandin) Action—stimulate insulin release from the pancreas in response to a glucose load Adverse Reactions – Nursing considerations:

38. Thiazolidinediones Examples—rosiglitazone (Avandia- now off market), pioglitazone (Actos) Action—decrease insulin resistance and increase insulin sensitivity by modifying several processes Adverse Reactions— Nursing considerations:

39. Combination Agents Metaglip- glipizide and metformin Glucovance-glyburide and metformin Actoplus Met- pioglitazone and metformin Avandamet- rosiglitazone and metformin Duetact- Pioglitazone and glimepiride Avandaryl- rosiglitzone and glimepride

40. Pharmacologic Algorithm for Treating Type 2 Diabetes See text, page 422

41. Emergency Medications to Elevate Glucose Glucagon IM (glucagon is a hormone produced by the alpha cells of the pancreas-stimulates the conversion of glycogen to glucose in the liver.. return to consciousness within 5-20 minutes) IV D50

42. Key Concepts

43. Case Study Timothy Jones is admitted to your unit with a diagnosis of new onset type 1 diabetes mellitus. His blood sugars have stabilized and he is beginning to ask questions. How would you answer the following questions? What is diabetes? Why can’t I be on pills instead of insulin? Why do I have to test my blood sugars? What should I do if it is too high or too low? Does insulin have any side effects? What should I watch for?