1. 2D-NMR

2. COSY, CO rrellation S pectroscop Y

3. COSY http://www.chem.queensu.ca/FACILITIES/ NMR/nmr/chem806/Web/homo2_files/frame.htm

4. COSY, COrrellation SpectroscopY

5. 2D-NMR: COSY C 5 H 10 O 2 IR: 1730 and 1200 cm -1, no peaks above 3000 cm -1

6. COSY: C 5 H 10 O 2

7. 2D-NMR: COSY C 6 H 12 O 2 IR: 1730 and 1200 cm -1, no peaks above 3000 cm -1

8. 2D-NMR: COSY

9. 1H2H3H 21 C 4 H 9 Cl 2D-NMR: COSY

12. C 14 H 20 O 2 (ester) 2D-NMR: COSY

13. C 14 H 20 O 2 2D-NMR: COSY

14. Given the COSY on the next page, assign all protons and calculate coupling constants, J 23, J 24 and J 34 ? (Because of the heterocyclic ring, H-2 has the highest chemical shift and the ortho coupling constant J 2-3 ~ 4Hz, significantly smaller than a normal ortho coupling constant.

15. 2D-NMR: COSY

16. Problem - Identify where the methyl is located on the quinoline Ring and assign all protons. Show correlation lines on the COSY spectrum to support your assignments.

17. 2D-NMR 1 H- 13 C Correllation Spectroscopy (HETCOR, HMQC, HSQC)

18. 2D-NMR 1 H- 13 C Correllation Spectroscopy (HETCOR, HMQC, HSQC) C 5 H 10 O

19. C4H9IC4H9I

20. C4H9IC4H9I COSY HMQC

22. Unknown: C 10 H 12 O