1. Cartilage and Bone Robert Scranton© 2008

2. Cartilage Few or many cells? Cell name? Vascular? The dense CT covering is _________, except for around __________ Matrix-  CT+ ground substance  Collagen, type___  GAG= “keratin/ chondroitin sulfate  Chondronectain  Bound water  Territorial v. interterritorial

3. Cartilage Perichondrium Define it  dense CT covering all cartilage but articular Layers Functions:  Nutrition  Growth  Repair  Attachment point

4. Cartilage Word Games Cell nests Perichondrial growth Hypertrophy Alkaline phosphatase v. hydroxyapatite crystals Fibrillin +elastin

5. Cartilage Types Hyaline, elastic, fibro  Give location, characteristics TypeLocationCharacteristics Hyalinearticular, larynx, trachea, bronchi, costal Type II Collagen, GAGs, chondronectin, bound water Elasticauricles, ext. auditory tube, eustachian tube, epiglottis like hyaline, but with elastic fibers FibroIntervertebral disks, pubic symphysis, TMJ like dense irregular CT, Collagen type I&II, very little ground substance

6. Cartilage Hyaline

7. Cartilage Hyaline

8. Cartilage Elastic

9. Cartilage Fibro

10. Cartilage Example of Articular Cartilage

11. Bone Epiphysis Diaphysis Metaphysis (in growing child) Epiphysis

12. Bone Word Games Compact bone= ____bone Cancellous bone= ____ bone and has ___ which are _____ The space b/w trabeculae and spicules filled with hematopoietic or fatty tissue. Diploe Immature bone, give syn.  Found during Secondary Bone Osteon

13. Bone Periosteum & Endosteum Periosteum, how many layers?  2- fibrous +osteogenic  How does it attach to bone?  Sharpey’s fibers=  Function?  Appositional growth  Repair  Attachment for ligaments and tendons  sensation

14. Bone Periosteum & Endosteum Endosteum, how many layers?  What type of cells?  osteoblasts

15. Bone Name the major players  Osteoblasts  Osteocytes  Osteoclasts  Matrix

16. Bone Name the major players  Osteoblasts  Active, mitotic  Osteocytes  Osteoclasts  Matrix

17. Bone Name the major players  Osteoblasts  Osteocytes  Surrounded by matrix  Can’t divide  Lacunae & canaliculi  Osteoclasts  Matrix

18. Bone Name the major players  Osteoblasts  Osteocytes  Osteoclasts  Derived from?  Function?  Located in?  Synthesize and secrete?  Matrix

19. Bone Name the major players  Osteoblasts  Osteocytes  Osteoclasts  Derived from?  Function?  Located in?  Synthesize and secrete?  Matrix

20. Bone Name the major players  Osteoblasts  Osteocytes  Osteoclasts  Matrix  Inorganic> Organic  Inorganic- hydroxyapatite, rigidity  Organic- Type I collagen, GAG, elasticity  Bone is vascular

21. The Haversian System

22. The Volkmann’s Canal

23. The Haversian System

24. Haversian Canal Volkmann’s Canal Bone

25. Hormone Effects

28. Don’t neglect Section on Spongy Bone Joints  What is the origin of the secretory epithelial lining the joint space