1. Ch 23 Catalysis 1. List three ways a catalyst can speed up a reaction.

2. Ch 23 Catalysis 2. Identify the type of catalysis in the following, and draw arrows to show the mechanism. a. b.

3. Ch 23 Catalysis c. d. e.

4. Ch 23 Catalysis 3. Propose a mechanism for the following that involves a general acid catalyst

5. Ch 23 Catalysis 4. Propose a mechanism for the following that involves a general base catalyst

6. Ch 23 Catalysis 5. What are three factors that determine the rate of a reaction? 6. How does the rate of an intramolecular reaction compare to an intermolecular one?

7. Ch 23 Catalysis 7. Which of the following will react more rapidly? a. Elimination of HBr

8. Ch 23 Catalysis b. Lactone formation c. Anhydride formation

9. Ch 23 Catalysis d. Reaction with ethanol

10. Ch 23 Catalysis 8. What role does imidazole play in catalyzing the following reaction?

11. Ch 23 Catalysis 9. Explain the difference between the lock-and- key versus the induced fit model. 10. List three ways an enzyme can catalyze a reaction.

12. Ch 23 Catalysis 11. Analyze the catalysis of carboxypeptidase A:

13. Ch 23 Catalysis continued:

14. Ch 23 Catalysis 12. Analyze the catalysis of chymotrypsin:

15. Ch 23 Catalysis continued:

16. Ch 23 Catalysis continued:

17. Ch 23 Catalysis 13. Analyze the catalysis of lysozyme: