1. Intro to Endocrine

2. What do you know about these terms? Membrane Transport Hormone Negative and positive feedback Cholesterol Membrane protein phosopholipid Selective Permeability Cholesterol Membrane protein Hydrophilic Hydrophobic

3. Review of the Membrane

4. Key Membrane Terms Phospholipid Molecule –Hydrophilic/hydrophobic (polar/non-polar) Cholesterol Membrane protein

5. Plasma Membrane: the outer boundary of a cell that encloses the cells contents.

6. Selective Permeability: some molecules are able to pass while others are not. –Tea bags, colanders, plasma membranes(!!)

7. Hydrophilic: water loving Hydrophobic: fear of water What kind of reaction occurs when you put a hydrophobic substance in water? –Think oil and vinegar

8. Fluid Mosaic Model

9. Three Parts to a Cell Membrane Phospholipid molecules –(formed into a phospholipid bilayer) Cholesterol molecule Membrane protein

10. Phospholipid Molecule Structure Two fatty acids and one phosphate head. The fatty acids are hydrophobic and the phosphate head is hydrophilic. Function The phospholipids pair up, and form a bilayer with the fatty acids touching, and the phosphate heads facing outwards. This creates the cell membrane

11. Phospholipid Molecule Unsaturated fatty acid what’s this?

12. Cholesterol Molecule Structure Rigid molecules embedded in the lipid bi-layer Function Helps keep the structure of the membrane and keeps the fatty acid tails anchored together.

13. Cholesterol in Plasma Membrane Where is the hydroxyl of the cholesterol?

14. Membrane Proteins Structure Proteins are located throughout the membrane (like raisins in a slice raisin bread) Function Regulation of what passes through the membrane Serve as enzymes and take part in chemical reactions Act as markers that are recognized by chemicals in and out of the cell

15. Membrane Proteins

16. Passive Transport Diffusion Facilitated diffusion ligand-gated ion channel osmosis

17. Active Transport http://programs.northlandcollege.edu/biolo gy/Biology1111/animations/transport1.htmlhttp://programs.northlandcollege.edu/biolo gy/Biology1111/animations/transport1.html proton pump Endo and exocytosis

18. Steroid Signals http://highered.mcgraw- hill.com/sites/0072437316/student_view0/ chapter47/animations.html#http://highered.mcgraw- hill.com/sites/0072437316/student_view0/ chapter47/animations.html#

19. Protein Signals http://entochem.tamu.edu/G- Protein/index.htmlhttp://entochem.tamu.edu/G- Protein/index.html

20. Intro to Endocrine/Negative Feedback http://health.howstuffworks.com/adam- 200092.htmhttp://health.howstuffworks.com/adam- 200092.htm