1. Drug Investigation Assignment

3.  Depressant that acts on CNS  Naturally found in CNS › Protects cells from oxygen starvation  Odorless  Colorless  Nearly Tasteless  Can be liquid, pill, or powder  Can be felt within the first 10-20 min

5.  FDA Banned GHB  GHB makers came out with GBL  Used as sleep aid & muscle enhancer  Street Names: firewater, lactone, blue nitro, vitality  FDA banned GBL too http://www.youtube.com/watch?v=RncP4cem5XI&feature=fvst

6.  January 31, 2000  Controlled Substance  Schedule 1  FDA approved Schedule 4

7.  1920- First synthesized  1960s- Used as anesthetic & hypnotic  1980s- Becomes available in food stores  1990- FDA bans over-the counter- Sale  1997-99- U.S. states place GHB in schedules 1-5  2000-02- Becomes illegal, FDA approves Xyrem for narcolepsy

8.  Anesthetic  Hypnotic  Clinical Depression  Alcoholism  Narcolepsy/insomnia

9.  Low Dose-Moderate › Increased sex drive › Dizziness › Slow heart rate › Muscle tremors  High Dose: › Sweating › Blackouts/memory lapses › Respiratory arrest › Loss of coordination  Overdose: › Nausea/vomiting › Seizures › Amnesia › Irregular/shallow breathing

10.  Feelings of Euphoria  Confusion  Hallucinations  Lowered Inhibitions

11. GHB DoseCommon Effects 1 gram or less Relaxation similar to alcohol intoxication 1 to 2 grams Euphoria, reduced inhibitions, enhanced sensuality and sexuality, increased sensory stimulation 2 to 4 grams Speech and motor skill interference 4 or more Agitation, combativeness, confusion, loss of coordination, seizure-like posturing of the limbs, respiratory depression, urinary and fecal incontinence, vomiting, wavering states of consciousness, overdose death

13.  http://www.erowid.org/chemicals/ghb/ghb.sht ml http://www.erowid.org/chemicals/ghb/ghb.sht ml  http://www.aafp.org/afp/20001201/2478.html http://www.aafp.org/afp/20001201/2478.html  http://www.psychoactive.org.uk/GHB/descripti on.htm http://www.psychoactive.org.uk/GHB/descripti on.htm  http://www.911rape.org/rape- drugs/ghb/street-names http://www.911rape.org/rape- drugs/ghb/street-names