1. Improving Breast Biopsy using IVUS probes Client: Dr. KelczTeam: Megan Buroker Kevin Johnson Advisor: Prof. Justin WilliamsNoelle Simatic Joe Zechlinski

3. Problem Statement  Goal  To improve biopsy yield by local imaging during MRI and Ultrasound guided stereotatic biopsy procedure.  Motivation  During biopsy procedures small tumors are often covered up by the biopsy needle yielding procedures with low specificity.

4. Guided Core Biopsy First visit  Initial mammographic/MR image  Positive diagnosis— suspicious lesions Second visit  Second MR image—insertion of plastic clip  Third MR image—check placement  Needle Insertion  Exact location never verified  Perform biopsy Results  Pathological analysis

6. Design Alternative 1 Optical Fluorescence  Prof. Nimmi Ramanujam  Photons excite tissue  Molecules emit frequency shifted photons  Fiberoptics record and transmit IR waves  Characteristic tissue response  NADH, FAD, and collagen

7. Design Alternatives 2 & 3 Intravascular Ultrasonic Probes  Used to Image Arteries  Consist of Catheter & Ultrasonic Probe  2-3 mm in diameter  Allow cross-sectional imaging of arteries  Depend on reflection of imaging area  Image 1-2 cm around probe  Waves 20-30Mhz

8. Design Alternative 2 Ultrasonic Biopsy Needle  Create a biopsy needle with a built in probe  Allows for 360 degree imaging  Would require a multi-transducer array  Needs to be sterile  Requires redesign of IVUS probe  Could be modified to incorporate 3D ultrasonic micro arrays in the near future

9. Design Alternative 3 Catheter Based IVUS Probe  Use existing IVUS probes  Insert probe between scans  Allow for limited view outside  Use either rotational IVUS or multi-transducer type  No new materials needed

10. Design Comparison Fiberoptic Integrated IVUS Catheter IVUS Fiberoptic Integrated IVUS Catheter IVUS Price 2 0 10 Measurement 8 10 5 MRI Compatibility 10 7 7 Ease of Use 7 10 7 Ethics of use 2 9 9 Total 29 36 38

11. Future Work  Testing  Phantoms  Real specimens  Possible re-build of IVUS probe into needle  Rotational vs. multi-transducer models in catheter based measurement

12. Questions?