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Recombinant Human Bone Morphogenetic Protein-2 Accelerates Healing in a Rabbit Ulnar Osteotomy Model by M. L. Bouxsein, T. J. Turek, C. A. Blake, D. D’Augusta,

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Presentation on theme: "Recombinant Human Bone Morphogenetic Protein-2 Accelerates Healing in a Rabbit Ulnar Osteotomy Model by M. L. Bouxsein, T. J. Turek, C. A. Blake, D. D’Augusta,"— Presentation transcript:

1 Recombinant Human Bone Morphogenetic Protein-2 Accelerates Healing in a Rabbit Ulnar Osteotomy Model by M. L. Bouxsein, T. J. Turek, C. A. Blake, D. D’Augusta, X. Li, M. Stevens, H. J. Seeherman, and J. M. Wozney J Bone Joint Surg Am Volume 83(8):1219-1230 August 1, 2001 ©2001 by The Journal of Bone and Joint Surgery, Inc.

2 In vivo (left panel) anteroposterior and mediolateral (middle panel) radiographs and representative histological section (right panel) showing the site of the ulnar osteotomy. M. L. Bouxsein et al. J Bone Joint Surg Am 2001;83:1219- 1230 ©2001 by The Journal of Bone and Joint Surgery, Inc.

3 Graph depicting the retention of rhBMP-2 at the ulnar osteotomy site, expressed as a percentage of the initial dose delivered (left axis) and as the absolute amount of protein remaining (right axis). M. L. Bouxsein et al. J Bone Joint Surg Am 2001;83:1219- 1230 ©2001 by The Journal of Bone and Joint Surgery, Inc.

4 Graphs showing the effect of absorbable collagen sponges (ACS) containing rhBMP-2 on failure torque (A), torsional stiffness (B), and energy absorbed to failure (C), expressed as percentages of the values for an intact limb. M. L. Bouxsein et al. J Bone Joint Surg Am 2001;83:1219- 1230 ©2001 by The Journal of Bone and Joint Surgery, Inc.

5 Representative histological sections of the ulnar osteotomy site at three weeks (top row), four weeks (middle row), and six weeks (bottom row). M. L. Bouxsein et al. J Bone Joint Surg Am 2001;83:1219- 1230 ©2001 by The Journal of Bone and Joint Surgery, Inc.

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