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Published byPhillip Underwood Modified over 9 years ago
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Objectives The aim of this study was to examine the relationship between dietary habits and 25(OH)D status in obese children. Examine the relationship between 25(OH)D and glucose homeostasis. Cross-sectional observational study
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Selection of Subjects 411 obese children (BMI >95 th percentile for age group) ages 6-16 Recruited from Center of Obesity and its Consequences on Health in Dallas, Texas 89 non overweight children Recruited from Endocrinology Center after being treated for hypothyroidism or GH deficiency, but otherwise healthy Exclusion criteria: use of anticonvulsant, vitamin D supplement more than 400 IU/day, other relevant disorders
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Data collected Age, sex, ethnicity, height, weight, blood pressure, dietary habits Laboratory data Serum 25(OH)D HbgA1C Fasting glucose and insulin OGTT HOMA-IR
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Statistical Analysis Prevalence of Vit D insufficiency determined for obese and non-overweight populations within each ethnic group and season Data collected in summer, fall, winter, spring Sufficiency: 75 nmol/L Insufficiency: < 75 nmol/L Deficiency: < 50 nmol/L χ squared to determine prevalence rate
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Statistical Analysis cont. Two way ANOVA to compare 25(OH)D between groups and assess interaction btw obesity and season; gender and ethnicity Pearson coefficients used to determine relationship btw 25(OH)D and: 2h glucose HbbA1c HOMA-IR Blood pressure
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