1. Principles of MRI magnetic resonance imaging
Dr Mohammed Bader Hassan
FIBMS,DMRD

2. Objectives By the end of this lecture the student should be able to
1.calrify the basics of MRI physics
2.define major MRI sequences (T1&T2)
3.identify the MRI advantages and contraindications
4.identify the major MRI studies such is angiography, MRCP and myelography

3. Basic facts
the human contain a predominant of hydrogen atoms (in water ,fat ,and other tissues)
The hydrogen atom contain a proton only
The proton is a particle with a positive charge
Each proton have a spin movement
The moving charge is electrical current which have magnetic field
So each proton have own magnetic field

4. P =
No Net
Magnetization

5. What happen when the body inside the magnetic field
1.the proton (small magnets )organize the selves with the external magnets
2.a precession movement begin (just like when you hit the top of spin )it is a wobble movement
This precession have the specific frequency according to type of atom and magnetic field (so it is a well known frequency)

6. how can we get a picture from MRI
It is difficult to measured aligned magnets inside a river of magnetic field so we should shift this magnetic field
We send a radio wave in the same frequency of the precession of the proton (radio frequency )resonance!

8. Measuring Tissue Magnetization:
For an energy transfer to occur the RF Pulse must be at the same
frequency as the precessing Mo. ie The Resonance Frequency.
Much like a tuning fork experiment. A B C D E B

9. Measuring Tissue Magnetization:B C D E B

10. Measuring Tissue Magnetization:B C D E B

11. Measuring Tissue Magnetization:B C D E B

12. Measuring Tissue Magnetization:B C D E B

13. What happen after radiofrequency is sent
The radio frequency should be in the same frequency of the precession of proton so it can transfer energy to proton
The energy which is picked up by proton will make the proton in higher energy this will make the longitudinal magnetic vector of the body is zero
And it will synchronized the precession of the protons which will move in the same direction & will give moving transverse vector

14. Moving transverse vector

15. What happen after the radiofrequency is off
The energy will be loosed from the spinning proton and longitudinal vector appear again in a specific time according to tissue component.
The synchronization (the transvers vector will be loosed in specific time according to tissue component

16. T1 Relaxation

17. T1 Relaxation z'
T1=the time which is needed for most of the longitudinal vectored to re appear y' x'
T1 relaxation is regrowth of the longitudinal magnetization

18. T1 Relaxation z' y' x'
T1 relaxation is regrowth of the longitudinal magnetization

19. T1 Relaxation z' y' x'
T1 relaxation is regrowth of the longitudinal magnetization

20. T1 Relaxation z' y' x'
T1 relaxation is regrowth of the longitudinal magnetization

21. T1 Relaxation z' y' x' Mlong = M0
T1 relaxation is regrowth of the longitudinal magnetization

22. T2 Decay
The time which is needed to disappear of most of the transverse vectored is T2 - + + z' z' - - + y' y' x' x'
T2 relaxation is dephasing of transverse magnetization

23. Decay of transvers vectoreT2
Transverse vector

24. MR SIGNAL Collected by a coil
Encoded through a series of complex techniques and calculations (magic?)
Stored as data
Mapped onto an image matrix

25. T1 Relaxation: With no other signal considerations
this would mean that the protons
with short T1 time would
contribute the highest signal
on the image.
Pixel containing protons
with short T1 time.
(eg Fat)

26. T2 Decay: With no other signal considerations
this would mean that the protons
with a long T2 time would
contribute the highest signal
on the image.
Pixel containing protons
with long T2 time.
(eg Water)

27. Time from the application of one RF pulse to another RF pulse
TR - REPETITION TIME
Time from the application of one RF pulse to another RF pulse
TE - ECHO TIME
Time from the application of the RF pulse to the peak of the signal induced in the coil

28. Image formation
The image will depend on T1,T2, and amount of proton within the tissue (spin density ) .
The fatty tissues is loosing energy quickly so it will re appear its longitudinal vector rapidly ( high T1 signal)
Fatty tissue will loss synchronization quickly
Water loosing energy and synchronization slowly so it will appear bright at T2 and black on T1
Solid material will not give a signal on t1 and t2 (signal void )
air will appears signal void because lack of H .

29. T1 WEIGHTING T2 WEIGHTING
A short TR and short TE will result in a T1 weighted image
Excellent for demonstrating anatomy
T2 WEIGHTING
A long TR and long TE will result in a T2 weighted image
Excellent for demonstrating pathology
MANY OTHER DIFFERENT TYPES OF IMAGES THAT COMBINE ABOVE AND INCLUDE OTHER PARAMETERS

30. Relative Relaxation Rates
Time
Color in image
Solid (bone ,stone )
Long
black
short
Black
semi-solid (muscle )
intermediate
liquid
long
dark
bright
Fat
Dark

31. T1-, -, and T2-weighted images

32. Brain Tumor Imaging T1-weighted Sagittal
What’s changed between these images?
T1-weighted Axial
T2-weighted Axial

33. STIR = Short Tau Inversion
Recovery
FAT

34. STIR = Short Tau Inversion
Recovery
FAT

35. STIR = Short Tau Inversion
Recovery
FAT

36. STIR = Short Tau Inversion
Recovery
FAT

37. STIR = Short Tau Inversion
Recovery
FAT

38. STIR = Short Tau Inversion
Recovery
FAT
90 deg
Very Small transverse component = small signal

39. STIR = Short Tau Inversion
Recovery
Fat & water

40. STIR = Short Tau Inversion
Recovery
Fat & water

41. STIR = Short Tau Inversion
Recovery
Fat & water

42. STIR = Short Tau Inversion
Recovery
Fat & water

43. Fat & water
STIR = Short Tau Inversion
Recovery

44. STIR = Short Tau Inversion
Recovery
Fat & water
90 deg
Water will have signal. Fat will not!

45. Advantage of MRI Non ionizing radiation
Multiplanar images (cross section , saggital and coronal views )
The ability of imaging vessels without contrast (MR angiography )
Have a good soft tissue contrast

46. Contraindication of MRI
Patient with pacemaker
Patient with bullet injury or ferromagnetic F.B ,or surgical clip (because of heat and missile effect )
Pregnancy especially first trimester
Claustrophobia reported that between 1 % and 10 % of patients experience some degree of claustrophobia which in the extreme cases results in their refusal to proceed with the scan

47. bioeffect
No known or expected harmful effects on humans using field strengths up to 10 Tesla
Currently pregnant women are normally excluded from MRI scans during the first trimester although there is no direct evidence to support this restriction
The most invasive MR scans involve the injection of contrast agents (e.g. Gd-DTPA).
noise

48. DISADVANTAGES OF MRI Expensive Long scan times
Audible noise (65-115dB)
Isolation of patient (claustrophobia, monitoring of ill patients)
Exclusion of patients with pacemakers and certain implants

49. THE CHANGING MAGNETIC FIELDS CAN DO DAMAGE TO:
Monitoring equipment
Infusion pumps
Credit cards
Cellular telephones
Any electronic device

50. THE FOLLOWING ARE (USUALLY*) OKAY:
Gold
Silver
Digital watches
Eyeglass frames
Snaps/zippers fastened to clothing
Dental work

51. Special MRI studies
MR angiography :non-invasive imaging of the vascular tree , In normal circumstances flow effects cause unwanted artefacts, but in MRA these phenomemna are used advantageously ,

52. Direction of
Blood Flow.

53. Direction of
Blood Flow.

54. Direction of
Blood Flow.

55. Direction of
Blood Flow.

56. Overall signal
from Voxel is
reduced due to
Phase Loss.
Direction of
Blood Flow.

57. Vascular Techniques 2D ToF Blood flowing into
the slice is fully magnetized
so when it receives an
RF pulse it is flipped
into the transverse
plane and gives
a high signal.
Arrows represent
Mo Vector

58. Vascular Techniques 2D ToF Stationary tissue receives
continual RF pulses that
arrive before the proton
can relax back to Bo.
This causes
Saturation of the
stationary tissue
and therefore less signal
from the stationary tissue.
2D ToF sequences
utilize short TR’s and
high flip angles.
Eg: 33ms & 70deg.

59. Vascular Techniques 2D ToF Blood flowing into
the slice is fully magnetized
so when it receives an
RF pulse it is flipped
into the transverse
plane and gives
a high signal.
Arrows represent
Mo Vector
Venous Flow
Direction

60. By placing an additional 90deg RF pulse in the path of the venous
blood we can
saturate its signal
before it enters the
imaging slice.
This is referred to
as a Pre-Saturation
Pulse.
Venous Flow
Direction

61. Vascular Techniques 2D ToF The resultant image shows
flowing blood with
bright signal and the
stationary tissue
as a “saturated”
signal.
The venous blood is saturated
in the same manner as stationary
tissue and contributes no signal.

62. Vascular Techniques 2D ToF By acquiring many individual slices long
vessels may be covered
easily. The resulting slices
are then combined and
viewed as a maximum
intensity projection (MIP)
in any orientation.

63. Vascular Techniques 2D ToF The resultant image may be rotated, paged
and manipulated to
demonstrate the
optimum viewing
plane.
(With IVI or AW
software packages)

65. MRCP Magnetic resonance colangio pancreaticography:
Heavily T2 weighted imaged for biliarry and pancreatic tree
No need for contrast
No need for endoscopy
Non invasive method

66. Normal duct stone

67. MR mylogarphy
Heavily T2 weighted image ,used for imaging spinal canal and theca sac , with out the need for injection of contrast in the thecal sac ( non invasive method )

69. QUESTIONS?????

70. Thank you