1. Central Nervous System and Epidermis

2. Neurulation What are the major derivatives of the ectoderm? What are the major derivatives of the ectoderm?

3. Neurulation What is the difference between primary and secondary neurulation? What is the difference between primary and secondary neurulation?

4. Primary Neurulation What are the major events of primary neurulation? What are the major events of primary neurulation?

5. Primary Neurulation What is involved in the shaping of the neural plate? What is involved in the shaping of the neural plate?

6. Primary Neurulation What is responsible for the bending of the neural plate? What is responsible for the bending of the neural plate?

7. Primary Neurulation How does neural tube closure compare in birds and mammals? How does neural tube closure compare in birds and mammals?

8. Primary Neurulation What causes spina bifida and anencephaly in human development? What causes spina bifida and anencephaly in human development?

9. Primary Neurulation What allows the neural tube to separate from the overlying ectoderm? What allows the neural tube to separate from the overlying ectoderm?

10. Secondary Neurulation Where can secondary neurulation be seen? Where can secondary neurulation be seen?

11. Neural Tube Differentiation Differentiation occurs on three levels Differentiation occurs on three levels gross anatomical gross anatomical bulges and constrictions bulges and constrictions parts of brain and spinal cord parts of brain and spinal cord tissue changes tissue changes rearrangements of different cell populations rearrangements of different cell populations forms functional regions forms functional regions cellular changes cellular changes neurons neurons glial cells glial cells

12. Anatomical Differentiation

13. Tissue Differentiation What appears to be responsible for ventral patterning of neural tube? What appears to be responsible for ventral patterning of neural tube? How can this been demonstrated experimentally?

14. Tissue Differentiation What appears to be responsible for dorsal patterning of neural tube? What appears to be responsible for dorsal patterning of neural tube?

15. Tissues of the CNS What are the three major layers formed in the spinal cord and medulla? What are the three major layers formed in the spinal cord and medulla?

16. Tissues of the CNS

17. How is the cerebellum organized? How is the cerebellum organized?

18. Tissues of the CNS How is the cerebrum organized? How is the cerebrum organized?

19. Tissues of the CNS How do we know that neural stem cells exist in the adult brain? How do we know that neural stem cells exist in the adult brain?

20. Vertebrate Eye What inductive event initiates eye formation? What inductive event initiates eye formation?

21. Vertebrate Eye Into what type of structure does the neural retina differentiate? Into what type of structure does the neural retina differentiate?

22. Vertebrate Eye How does cornea and lens differentiate? How does cornea and lens differentiate?

23. Epidermis Epidermis develops from outer ectodermal cells Epidermis develops from outer ectodermal cells first 2 layers form first 2 layers form periderm periderm basal layer basal layer then 5 layers form then 5 layers form

24. Epidermis What growth factors are involved in epidermal development? What growth factors are involved in epidermal development?

25. Cutaneous Appendages How do cutaneous appendages such as hair, scales, feathers and glands form? How do cutaneous appendages such as hair, scales, feathers and glands form?

26. Cutaneous Appendages What is known about the genetic control of hair formation? What is known about the genetic control of hair formation?

27. Cutaneous Appendages