1. UCLA CTSI KL2 Translational Science Award Mitchell Wong, MD PhD Director, KL2 Program

2. Award Overview Career development support for junior faculty within the UCLA CTSI Consortium Interdisciplinary, translational science (basic, clinical and HSR) Similar in structure to K08/K23 award

3. Support Annual award, renewable for up to 3-years Support –$75k salary plus benefits –$25k research support –$4k for tuition or coursework –$2k for travel –$1500 for statistical support in addition to in- kind support from DOM Stats

4. Eligibility Doctoral level research degree or professional degree (with advanced research training) Faculty level title as of July 1, 2014 at a UCLA CTSI Institution Commit 75% of effort to translational research and aims of the KL2 (50% minimum for some specialties like surgery) U.S. Citizen or non-citizen national, permanent U.S. resident

5. Eligibility (Prior/Pending Grants) May have had a small grant (R03, R21) May have had prior K12 funding (total K funding cannot exceed 5 years) Cannot have: –Prior or current PI of a NIH R01 or equivalent grant (direct costs>$100k per year) –Prior or current PI of a K08/K23 award –Prior or current PI of a VA Career Development or R01 Equivalent grant –PI of a pending K award application, pending R award in similar area –Current co-investigator funding on an R01/Project grant

6. Future Funding for KL2 KL2 Awardees may apply for K08/K23 or VA CDAs –Must relinquish KL2 if awardee receives NIH/VA CDA –Total CDA funding (KL2 + individual CDA) cannot exceed 5 years. KL2 Awardees may apply for R01, Program grants –Must maintain 75% effort on KL2 in year 1 –May decrease to 50% effort in last 2 years of K support

7. Selection Criteria 1.Proposed research- Quality, innovation, significance, feasibility, promise for future funding, relevance to interdisciplinary, translational research 2.Candidate- Training, productivity, promise 3.Mentor- Track record in mentorship and research, commitment to candidate 4.Educational Plan- Well described and planned, fit with research plan, provides candidate with new skill set 5.(Environment)- Commitment from institution, department/division, availability of support and resources to conduct research and educational plan

8. Application Components Letter of intent- Name, mentor, title, biosketch, specific aims (to help KL2 selection committee identify appropriate reviewers) Application (6 pages)- Research, Education and Career Plan Mentor’s Letter (2 pages) Institutional Letter (2 pages) from department chair or division chief Letters of support (2 max) Candidate’s CV and other support page Mentor’s Biosketch Budget and budget justification References Data and Safety Monitoring Plan (when applicable) Appendices allowable (e.g. letter of support for use of equipment or data)

9. Timeline Letter of intent deadline February 3, 2014 Application deadline February 24, 2014 Awardees will be notified in late April 2014 Grant start date July 1, 2014 Research funds will not be released until IRB approval received