1. CardioInspect Diagnostic and Monitoring Systems
for Congestive Heart Failure (CHF) Patients
TAU Future Technology Development L.P.

2. Voltage Measurement Unit Control and Acquisition Unit
The Technology
EIT – Electrical Impedance Tomography
Electrical Impedance tissue property is imaged non invasively
Chest belt with
disposable electrodes
Current Source Unit
Voltage Measurement Unit
Control and Acquisition Unit
Reconstruction Algorithm

3. CardioInspect Standalone Prototype Clinical Trials

4. Clinical Results Monitoring Lung Edema Level
Improvement
+16%
+35%
Lung Resistivity [Ohm*cm]
Measurement #
Significant increase in resistivity values reflect improvement of lung fluid level

5. The Telemedicine Home System
Recording Phase
Transmitting Phase
Clinical data as received at the medical center

6. The Telemedicine Home System
Healthy Subject
CHF Patient

7. Diagnostic and Monitoring EIT System for Osteoporosis

8. Vision Statement
Revolutionize the diagnostics and monitoring of Osteoporosis in the clinic and at home by introducing an EIT based technology that can be integrated within a hand wristband

9. Proposed Solution
Deliver a novel Electrical Impedance Tomography (EIT) based technology as an alternative to the DEXA solution:
Inexpensive relative to other existing techniques
Does not utilize ionizing radiation and well suited for long-term tracking that is often required in Osteoporosis management
Utilized using simple and compact hardware; Can be applied in small clinics and at home
Utilizing EIT:
Provides information about the spatial electrical conductivity distribution within the human body
Based on applying small magnitude alternating electric currents to the body and measuring developing electric potentials on the body surface
The large variation in bone tissue electric and dielectric properties during Osteoporosis, makes EIT a promising technique for monitoring and diagnosing
Current Source Unit
Voltage Measurement Unit
Control and Acquisition Unit
Reconstruction Algorithm

10. Technical Background (1 of 4)
Mathematical Formulation
Forward formulation - Calculation of the spatial electrical potential due to known current sources and conductivity distribution
Inverse formulation - Calculation of the spatial conductivity distribution due to known current sources and surface voltages

11. Technical Background (2 of 4)
The Newton-Raphson algorithm
Initial Guess - 0
Forward Solver
Calculated surface potentials
Measured surface potentials
Cost function
<
yes
End no
k+1=k+k+1

12. Technical Background (3 of 4)
Numerical computational simulation
Displayed above are human body computerized model cross section results of the wrist and forearm as received from our preliminary numerical study, using a set of 5 electrodes on the surface of the wrist and measuring the surface potentials. Very strong correlation was found between the Impedance and BMD

13. Technical Background (4 of 4)
Preliminary real measurements using the developed prototype
The prototype during measurement
Results of 7 real tests from 5 healthy subjects and 2 patients with documented osteoporosis
Good correlation was obtained between the measured impedance and age