1. Pulmonary Embolism Extraction Catheter Development Trip Cothren Lauren Nichols Dustin Temple Advised by: Dr. Michael Barnett, VUMC Cardiology

2. Problem There are over 600,000 cases of pulmonary embolisms annually in the United States, which result in nearly 60,000 fatalities. Systemic thrombolytics can be dangerous Need a catheter that can quickly and effectively remove pulmonary embolisms

3. Goals The goal of this project is to design a catheter that can efficiently remove an embolism from the pulmonary artery. The main goals of the project are: To research and evaluate current technology in pulmonary embolism extraction To design a catheter that can successfully remove embolisms percutaneously and completely without damage to the patient To produce a feasible prototype of our design

4. Our Design Combined ideas from multiple existing medical products Inferior vena cava filter Absorbable hemostat Local clot busting drug administration Security from multiple backups

5. Filter Based off inferior vena cava filter Umbrella-like device Expandable to various sizes Use of Nitinol

6. Nitinol Different Nickel/Titanium composition Can be easily annealed and set Is used in orthodontics Biocompatible Advantageous price and strength

7. Preliminary CAD

8. Surgicel or Gelita Material that attracts clots Oxidized cellulose polymer Used clinically for over 50 years Coat prongs of filter Prevent clots pieces from going downstream Made by Ethicon

9. Trellis Catheter Device Inflatable back-end “clot-catching” device Local drug delivery Use of guide wire

10. Design Parameters Approximately 2 m in length Umbrella-like filter that deploys from tip Device expands to15 mm in diameter Clot attracting material coating filter Local thrombolytic injection to break up clot

11. Function Parameters Time frame of < 1 hr Embolus located via x-ray angiography Typically done by interventional radiology or cardiothoracic For use when systemic thrombolytics are not viable option

12. Potential Problems Hemolysis causes release of adenosine when cells lyse Bradycardia or heart failure Renal failure Unpredictable thrombolytic tolerance Mechanical damage to vessel wall

13. Current Work Decide local thrombolytic elution Choose best type of Surgicel or Gelita Develop Nitinol usage Refine model using Pro Engineer

14. Future Work Meet with Dr. Barnett and Dr. Bream to discuss feasibility of ideas Calculate force of push of memory wire against vessel wall Ensure biocompatibility of all materials Meet with Ethicon sales representative

15. References http://www.medgadget.com/archives/img /sidcath.jpg http://www.medgadget.com/archives/img /sidcath.jpg http://www.socalcardiology.com/media/a ngiojet.jpg http://www.socalcardiology.com/media/a ngiojet.jpg http://www.lexmed.com/images/cathphot o2.jpg