1. Dairy and Ovarian Cancer Publication Genkinger, JM, et al. Dairy Products and Ovarian Cancer: A Pooled Analysis of 12 Cohort Studies. Cancer Epidemiol Biomarkers Prev 2006;15(2):1-9.

2. Genkinger et al, 2006 Swedish Mammography Cohort (SMC) Netherlands Cohort Study (NLCS) New York State Cohort (NYSC) Iowa Women’s Health Study (IWHS) Canadian National Breast Screening Study (CNBSS) Cohort studies in the pooled analysis of dairy products and ovarian cancer Cancer Prevention Study II Nutrition Cohort (CPS II) Adventist Health Study (AHS) New York University Women’s Health Study (NYU) Breast Cancer Detection Demonstration Project Follow-up Study (BCDDP) Total cohort size= 553,217 Total # of cases = 2,132 Nurses’ Health Study (NHSa, NHSb), Nurses’ Health Study II (NHS II), Women’s Health Study (WHS)

3. Genkinger et al, 2006 Cohort studies in the pooled analysis of dairy products and ovarian cancer Study Follow-upYearsBaselineCohort#Cases AHS1976-198818,40253 BCDDP1987-199932,885142 CNBSS1980-200049,613223 CPS II 1992-200161,202278 IWHS1986-200128,486208 NLCS1986-199562,412208 NYSC1980-198722,55077 NYU1985-199812,40165 NHSa1980-198680,195120 NHSb1986-200259,538315 NHS II 1991-200091,50252 SMC1987-200461,103285 WHS1993-200432,466104

4. Genkinger et al, 2006 Mean (SD) of Dairy Nutrient and Food Intake StudyDietaryCalcium(mg/day)Total Calcium Calcium a(mg/day)Lactose(g/day)Dietary Vitamin D (IU/day)Total Vitamin D Vitamin D a(IU/day)TotalMilk(g/day) AHS 833 (124) 880 (139) 18 (14) ------ 419 (349) BCDDP 862 (369) 1186 (2979) 19 (14) 206 (122) 341 (279) 260 (269) CNBSS 673 (253) --- 8 (7) ------ 200 (199) CPS II 884 (379) 1136 (584) 19 (13) 197 (119) 342 (258) 277 (265) IWHS 748 (285) 1029 (483) 15 (11) 223 (111) 382 (292) 275 (265) NLCS 869 (259) --- 14 (7) ------ 187 (153) NYSC 828 (209) 873 (220) 15 (9) 203 (68) 371 (227) 137 (87) NYU 810 (307) 888 (327) 14 (11) ------ 202 (243) NHSa 722 (298) 731 (310) 14 (11) 167 (107) 279 (262) 215 (241) NHSb 718 (254) 1056 (492) 13 (10) 182 (100) 319 (243) 221 (230) NHS II 787 (271) 910 (381) 16 (11) 223 (109) 351 (231) 268 (255) SMC 913 (255) --- 16 (10) 162 (51) --- 156 (130) WHS 729 (258) 940 (442) 14 (10) 217 (104) 324 (216) 215 (222) a Total calcium and vitamin D intake includes dietary and supplemental sources.

5. Genkinger et al, 2006 Pooled Relative Risks for Ovarian Cancer According to Intake of Dairy Foods Food Intake (g/day) MilkRange01-69.970-124.9125-249.9250-499.9 >500 MV RR 95% CI 1.00 (Ref) (Ref)0.98(0.81-1.17)1.07 (0.84-1.35) (0.84-1.35)1.09 (0.87-1.36) (0.87-1.36)0.90(0.73-1.11)1.11 (0.87-1.41) (0.87-1.41) Low fat Low fatRange01-124.9125-249.9 >250 MV RR 95% CI 1.00 (Ref) (Ref)0.99(0.86-1.14)1.08(0.93-1.25)1.07(0.93-1.23) Whole WholeRange01-124.9125-249.9 >250 MV RR 95% CI 1.00 (Ref) (Ref)0.94(0.83-1.05)1.04(0.88-1.21)0.95(0.73-1.24) HardCheese Range01-24.925-49.9 >50 MV RR 95% CI 1.00 (Ref) (Ref)1.09(0.90-1.33)1.09(0.77-1.53)1.30 (0.96-1.78) (0.96-1.78) YogurtRange01-27.928-56.957-113.9 >114 MV RR 95% CI 1.00(Ref)0.97(0.85-1.10)0.87 (0.73-1.04) (0.73-1.04)0.89 (0.75-1.06) (0.75-1.06)1.04(0.86-1.24)

6. Genkinger et al, 2006 Pooled Relative Risks for Ovarian Cancer According to Intake of Dairy Nutrients NutrientIntake Dietary Calcium Range<500500-699.9700-899.9900-1099.91100-1299.9 > 1300 mg/day mg/day MV RR 95% CI 1.00(Ref)1.02 (0.88-1.18) (0.88-1.18)1.05(0.89-1.24)1.00 (0.79-1.27) (0.79-1.27)0.98 (0.79-1.21) (0.79-1.21)1.17(0.93-1.47) Total Calcium Range<500500-699.9700-899.9900-1099.91100-1299.9 > 1300 mg/day mg/day MV RR 95% CI 1.00(Ref)1.05 (0.84-1.30) (0.84-1.30)1.06(0.85-1.34)1.04 (0.82-1.32) (0.82-1.32)1.16(0.90-1.48)1.08(0.84-1.38) Dietary Vitamin D 1 Range<100100-199.9200-299.9300-399.9400-499.9 > 500 IU/day IU/day MV RR 95% CI 1.00(Ref) 1.05 (0.90- 1.23) 1.10 (0.93- 1.30) 1.05 (0.83- 1.33) 1.56 (1.17- 2.08) 1.37 (0.78- 2.40) Total Vitamin D Range<100100-199.9200-299.9300-399.9400-499.9 >500 IU/day IU/day MV RR 95% CI 1.00(Ref)1.20 (0.97-1.48) (0.97-1.48)1.26 (1.00-1.57) (1.00-1.57)1.09 (0.79-1.51) (0.79-1.51)1.27(0.98-1.64)1.12 (0.90-1.38) (0.90-1.38) 1 Significant P trend for dietary vitamin D p=0.008

7. Genkinger et al, 2006 Multivariate Adjusted Pooled Relative Risks for Ovarian Cancer According to Lactose Intake <10 785 1.00 (ref) 10-19.9 793 1.09 (0.97-1.22) 20-29.9 344 1.07 (0.91-1.25)  30 210 1.19 (1.01-1.40) Multivariate RR Lactose Intake (g/day) 1 serving of milk contains approximately 10g of lactose Range Cases MV RR

8. Genkinger et al, 2006 Study-specific Pooled Multivariate RRs of Ovarian Cancer and Lactose Intake (>30g/day compared to 30g/day compared to <10g/day) 1 serving of milk contains approximately 10g of lactose

9. Genkinger et al, 2006 Pooled relative risks for ovarian cancer according to dairy foods and nutrients, continuous model Increment Multivariate RR (95% CI) P Value for Heterogeneity Foods Milk250g 1.02 (0.97-1.08) 0.34 Low fat Milk Low fat Milk250g 1.04 (0.98-1.09) 0.64 Whole Milk Whole Milk250g 0.98 (0.88-1.10) 0.09 Cheese Hard Cheese Hard Cheese25g 1.02 (0.93-1.11) 0.17 Cottage Cheese Cottage Cheese105g 0.82 (0.63-1.08) 0.22 Yogurt55g 0.91 (0.77-1.07) 0.80 Nutrients Dietary Calcium 350mg 1.03 (0.97-1.09) 0.32 Total Calcium 350mg 1.01 (0.99-1.02) 0.41 Lactose10g 1.04 (0.99-1.08) 0.26 Dietary Vitamin D 100IU 1.06 (1.00-1.12) 0.28 Total Vitamin D 100IU 1.02 (0.99-1.04) 0.31

10. Genkinger et al, 2006 Multivariate Adjusted Pooled RR for Histological Subtypes of Ovarian Cancer According to Dairy Food and Nutrient Intake Increment Endometrioid Cases MucinousCasesSerousCases Foods Milk250g 1.10 (0.95-1.27) 0.97 (0.77-1.22) 1.06 (0.94-1.19) Cheese Hard Cheese Hard Cheese25g 1.11 (0.92-1.35) 1.00 (0.75-1.33) 1.07 (0.97-1.18) Cottage Cheese Cottage Cheese105g 0.95 (0.50-1.81) 1.59 (0.92-2.57) 0.90 (0.62-1.32) Nutrients Dietary Calcium 350mg 1.08 (0.93-1.25) 0.88 (0.70-1.11) 1.08 (0.97-1.21) 1 Total Calcium 350mg 1.08 (0.94-1.24) 1.08 (0.89-1.30) 1.00 (0.93-1.07) Lactose10g 1.07 (0.95-1.20) 0.97 (0.81-1.16) 1.06 (0.97-1.16) 1 Dietary Vitamin D 100IU 1.17 (0.97-1.42) 0.95 (0.73-1.24) 1.04 (0.98-1.12) Total Vitamin D 100IU 1.08 (1.02-1.15) 0.99 (0.85-1.10) 1.02 (0.94-1.09) 1 P Heterogeneity between studies for dietary calcium=0.02 P Heterogeneity between studies for lactose=0.03