1. Metabolic Syndrome: Focused on AMPK as Molecular Target for Metabolic Syndrome
Bayu Lestari

2. What will be Impaired in This Patient?
Insulin Resistance?
Dyslipidemia? (High TG, High LDL, Low LDL)
T2DM?
Metabolic Syndrome
Obese

3. Background
High prevalence of metabolic syndrome: relation between glucose and lipid metabolism
Various clinical manifestations: T2DM, obese, dyslipidemia
New therapeutic approach required for efficient and high efficacy
AMPK was reported as potent molecular target for metabolic syndrome therapy

4. Aim Discuss about Metabolic Syndrome
Discuss about AMPK as molecular target for therapy

5. Metabolic Syndrome
Cluster of syndrome: insulin resistance, high blood glucose, dyslipidemia, obese
Impairment both glucose metabolism and lipid metabolism
Correlation between glucose and lipid metabolism?

6. Glucose Transport and How Insulin Resistance Occur

7. How Lipid Disorder Affect Insulin Resistance

8. Structure of AMPK

9. Activation Pathway of AMPK

10. Regulation of AMPK

11. How AMPK Activation Reduce Metabolic Syndrome

12. Role AMPK on GLUT4 Enhanced translocation of GLUT4
Enhanced expression of GLUT4 gene (Zheng et al, 2009)
Insulin independent pathway?

13. mTOR Pathway

14. Role AMPK in Insulin Sensitivity
Insulin-mTOR pathway  activation & phosphorylation S6 kinase I, down-regulation insulin receptor substrate-1 (IRS1) decrease insulin signalling (Zheng et al, 2009)

15. Role AMPK in Mitochondrial Biogenesis
AMPK activation  improve mitochondrial function via expression of peroxisome proliferator-activated receptor-γ (PPAR-γ) coactivator-1α (PGC-1α)  reduce insulin resistance  reduce development of T2DM (Zheng et al, 2009)

16. Role AMPK in Lipid Metabolism
Lipid Oxidation
Lipogenesis

17. Conclusion
Metabolic syndrome: cluster of syndromes (insulin resistance, dyslipidemia, obese)
AMPK has beneficial role as molecular target for metabolic syndrome’s therapy

18. Thank You