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Box A The Remarkable Giant Nerve Cells of a Squid

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Presentation on theme: "Box A The Remarkable Giant Nerve Cells of a Squid"— Presentation transcript:

1 Box A The Remarkable Giant Nerve Cells of a Squid
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2 Box 3A The voltage clamp method
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3 3.1 Current flow across an axon membrane during a voltage clamp experiment. (Part 1)
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4 3.1 Current flow across an axon membrane during a voltage clamp experiment. (Part 2)
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5 3.2 Current produced by membrane depolarizations to several different potentials.
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6 3.3 Relationship between current amplitude and membrane potential.
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7 3.4 Dependence of the early inward current on sodium.
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8 Figure 3.5 Pharmacological separation of Na+ and K+ currents into sodium and potassium components

9 3.6 Membrane conductance changes are time- and voltage-dependent.
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10 3.7 Depolarization increases Na+ and K+ conductances of the squid giant axon.
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11 3.8 Mathematical reconstruction of the action potential. (Part 1)
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12 3.10 Passive current flow in an axon. (Part 1)
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13 3.10 Passive current flow in an axon. (Part 2)
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14 3.11 Propagation of an action potential.
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15 3.12 Action potential conduction requires both active and passive current flow. (Part 1)
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16 3.12 Action potential conduction requires both active and passive current flow. (Part 2)
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17 3. 13 Saltatory action potential conduction along a myelinated axon
3.13 Saltatory action potential conduction along a myelinated axon. (Part 1) neuro3e-fig jpg

18 3. 13 Saltatory action potential conduction along a myelinated axon
3.13 Saltatory action potential conduction along a myelinated axon. (Part 2) neuro3e-fig jpg

19 3.14 Speed of action potential conduction in unmyelinated and myelinated axons. (Part 1)
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20 3.14 Speed of action potential conduction in unmyelinated and myelinated axons. (Part 2)
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21 3.14 Speed of action potential conduction in unmyelinated and myelinated axons. (Part 3)
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22 Box C Passive Membrane Properties (Part 1)
Vx=voltage at distance x V0=voltage change at point of current injection l=axon length constant, distance from the site of current injection to where it is 1/e (about 37%)of V0 neuro3e-box-03-c-1.jpg

23 Box C Passive Membrane Properties (2)
t= time t=membrane time constant where Vt declines to 1/e or 37% of V∞ t= time t=membrane time constant where Vt rises to1-1/e or 63% of V∞ neuro3e-box-03-c-2.jpg


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