1. Confidential – For Internal Use Only QUANTOS PRISTIMA Automated Capsule weighing April 2015 Chris Wood

2. Confidential – For Internal Use Only ► Animals weighed and recorded ► Weights checked ► Target lists were calculated and checked after transcription of weights and dose levels ► Target list- manual request sheet brought to Dispensary ► Dispensary staff manually weighed to target into capsules, manually recording data, manually checking TA, dose pots and labels. ► 7 days of dosing. Depending on size of study, several technicians in several safety cabinets for hour after hour were employed, generating a manual “book” of data for a long term study. Once upon a time…..

3. Confidential – For Internal Use Only The problems  Took many hours of manual weighing  Many pages of manually recorded weighings  Many manual calculations  Many transcriptions  Messy buisness  Risk of exposure  Risk of RSI  Many manual checking procedures.

4. Confidential – For Internal Use Only Along came the Quantos…  Analytical balance with a automatic delivery system and a carousel.  It can weigh 30 weights automatically  Its clever delivery head actually works  Vibrates/pushes TA into the container/empty capsule  TA is enclosed in a sample bottle  Ideal for small runs like in our lab situation  Relatively inexpensive compared with other automated capsule filling devices.  Potential for limited/no exposure of TA to staff  Negligible losses of TA.

5. Confidential – For Internal Use Only The Good points  It worked.  Once it starts no operator is needed for 30 weighings  Significant labor saving  Can do mg level weighing faster than an operator.  Accurate  No mistakes  No losses  No exposure  Will check the correct material is loaded automatically  Some manual checking reduction  Variety of weighing containers can be used

6. Confidential – For Internal Use Only The problems  Will only weigh 30 weighings before changing the containers  Target weights over 100mg are slower than a manual operator.  Could use Mettler supplied software to capture data, but validation would be required.  Ticker tape printer is supplied – but still produces paper data.  Have to transcribe target weights into the balance  Needs manual checks  Still need to manually put the capsule into a labelled dosing pot and check it.

7. Confidential – For Internal Use Only Pristima developed an interface and we bought it.  It linked the advantages of the Pristima system with the Quantos.  New process  Animals weights captured on Pristima  Target weights automatically calculated  Straight into target list in Pharmacy  Load Quantos with empty capsules  Press “start on Pristima”  30 capsules done to variable target weights  Weights captured on pristima  Bar code scanning into correct dose pot

8. Confidential – For Internal Use Only More of the Good points  No manual data at all.  No manual involvement other than loading and unloading  No manual checking  No manual data recording  No errors  No data book  Now between half and two thirds faster than the “old method”

9. Confidential – For Internal Use Only Now for the Movie !

10. Confidential – For Internal Use Only