1. 1 HYPERSENSITIVITY A damage to host mediated by preexisting immunity to self or foreign antigen

2. 2 Impact of allergic diseases allergic condition estimated number affected (million) Allergic rhinitis19.6 Chronic sinusitis32.5 Contact dermatitis & eczema5.8 12Skin rashes Asthma9-12 Anaphylaxis1-2

3. 3 Types of hypersensitivity reactions Type I: anaphylactic or immediate Type II:cytotoxic Type III:Immune complex Type IV:cell mediated or delayed Type I: anaphylactic or immediate Type II:cytotoxic Type III:Immune complex Type IV:cell mediated or delayed

4. 4 Type-I hypersensitivity The common allergy

5. 5 Anaphylaxis can be fatal

6. 6 Many organ are be affected by “allergy” The nasohprynx Rhinorrhea

7. 7 Many organ are be affected by “allergy” The nasohprynx Nasal polyps

8. 8 Many organ are be affected by “allergy” The nasohprynx Tonsillitis

9. 9 Many organ are be affected by “allergy” The skin Urticaria (hives)

10. 10 Many organ are be affected by “allergy” The skin eczema

11. 11 Many organ are be affected by “allergy” The eye conjunctivitis

12. 12 Many organ are be affected by “allergy” The lungs asthma