1. D4FF55A0-6B6F-4181- 8802-07BF422A9BA9 Present by: Xiao Chen On December 7, 2015

2. WHAT IS IT?  Precision medicine is an emerging approach for disease prevention and treatment that takes into account people’s individual variations in genes, environment, and lifestyle.  The Precision Medicine Initiative will generate the scientific evidence needed to move the concept of precision medicine into clinical practice. www.nih.gov/precisionmedicineFront Psychiatry. 2015 Jun 8;6:88. doi: 10.3389/fpsyt.2015.00088. eCollection 2015.

3. WHY NOW ?  The time is right because of: Sequencing Improved New tools of the human technologies for for using large genome biomedical analysis datasets http://syndication.nih.gov/multimedia/pmi/infographics/pmi-infographic

4. NEAR TERM GOALS  Intensify efforts to apply precision medicine to cancer Innovative clinical trials Use of Knowledge to of targets drugs for combination overcome drug adult, pediatric cancers therapies resistance http://syndication.nih.gov/multimedia/pmi/infographics/pmi-infographic http://www.cancer.gov/research/key-initiatives/precision-medicine

5. LONGER TERM GOALS  Create a research cohort of >1 million American volunteers who will share genetic data, biological samples, and diet/lifestyle information, all linked to their electronic health records if they choose  Pioneer a new model for doing science that emphasizes engaged participants, responsible data sharing, and privacy protection. http://syndication.nih.gov/multimedia/pmi/infographics/pmi-infographic

6. Research based upon the cohort data will:  Advanced pharmacogenomics, the right drug for the right patient at the right dose  Identify new targets for treatment and prevention  Test whether mobile devices can encourage healthy behaviors  Lay scientific foundation for precision medicine for many diseases http://syndication.nih.gov/multimedia/pmi/infographics/pmi-infographic

7. 23andMe

8. Ancestry Composition

13. Traits

14. Drug Response

15. Inherited condition

16. Health Risk “These reports provide information about your possible risk for developing certain health conditions based on genetics. Environmental and lifestyle factors also often play a large role in your risk for developing these conditions.”