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Prepared by Kamal Hosny 11367 Maged Osama 11377
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under supervision of Prof./Sherein Saeid
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pulpy kidney
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Definition Pulpy kidney (enterotoxaemia) is a a common, per acute and usually fatal enterotoximic disease of sheep, goats and cattle. It occurs in sheep when a bacterium (C.perfringens type D) that normally inhabits the animal’s intestines without causing problems begins to multiply and produce toxins.
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the Epsilon toxin of C. perfringens type D Clostridium perfringens type D causes the highest number of sheep fatalities. It is a large, gram positive, anaerobic bacillus that is commensalises the gastrointestinal tract of most mammals cause
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Per acute sudden death Acute salivation and coma Sub acute neurological signs Symptoms
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Sudden change in diet (high CHO content ) Acidosis (good media for M.O multiplication) Secretion of Epsilon toxin Circulation of the toxin in the blood Endothelial injury Edema and hemorrhage in the brain and kidney Pathogenesis Pathogenesis
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Hemorrhage under the skin, heart and kidney Straw colored fluid or jelly like clot in the pericardial sac Postmortem
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Small intestine tear easily and its content is creamy. The kidney usually more dark and jelly like and decompose more rapidly than other organs.
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o The lamb found dead with extended limbs and head thrown back o The carcass is decomposed rapidly in few hours. N.B
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Kidney : Necrosis and degeneration of proximal convoluted tubules Microscopic
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Brain : Brain edema and hemorrhage around the capillaries symmetric encephalomalacia
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