1. Dr. Aya M. Serry Glomerulonephritis 2015

2. Glomerul/o/nephr/it is glomeruli kidney inflammation Alternative names: acute/chronic nephritis, glomerular disease  Definition: Type of kidney disease in which the part of the kidneys that help filter waste and fluids from the blood is damaged (Inflammed)  Glomeruli remove excess fluid, electrolytes and waste from your bloodstream and pass them into your urine  If the illness continues, the kidneys may stop working completely, resulting in kidney failure

3. Glomerulus Glomerulus – The filters of the kidneys which filter the blood and make urine

4.  Acute glomerulonephritis - begins suddenly  Chronic glomerulonephritis -develops gradually over several years.  If glomerulonephritis occurs on its own, it's known as primary glomerulonephritis.  If another disease, such as lupus or diabetes, is the cause, it's called secondary glomerulonephritis

5.  Often, the precise cause of glomerulonephritis is unknown  Glomerulonephritis may be caused by specific problems with the body's immune system  Causes of glomerulonephritis may include: Streptococcal infection of the throat ( strep throat) or skin-- To fight the infection, your body produces extra antibodies that may eventually settle in the glomeruli, causing inflammation. Immune diseases, such as lupus diabetes High blood pressure Vasculitis (inflammation of the blood vessels) Viruses ( HIV, hepatitis B virus, and hepatitis C virus)

6. Most common symptoms:  Pink or cola-colored urine from red blood cells in your urine (hematuria)  Foamy urine due to excess protein (proteinuria)  Swelling of the face, eyes, ankle, feet, legs, abdomen  Increased Blood Pressure due to decreased GFR. This will lead to increased Renin release

7.  History of cancer  Blood or lymphatic disorders  Diabetes  Some Infections -Heart infections -Viruses

8. Because symptoms develop gradually, the disorder may be discovered when there is an abnormal urine analysis during a routine physical or examination for unrelated disorders Urine test Blood tests Imaging of the kidney Kidney Biopsy

9. TREATMENTS

10.  Treatment varies depending on the type and severity of symptoms  High blood pressure may be difficult to control, and it is generally the most important aspect of treatment  Dialysis and Transplant Medicines that may be prescribed include:  Blood pressure medications are often needed to control high blood pressure  Medications that suppress the immune system may also be prescribed (as in case of lupus)

11. THANK YOU…..