1. TASHKENT MEDICAL ACADEMY Department of Bioorganic and Biological Chemistry Bioorganic chemistry I COURSE SUBJECT : Bioactive Heterocyclic Compounds. Six Members Heterocycles. LECTURE №9 LECTURER : PROFESSOR A.D.DZHURAEV

2. PURPOSE OF LECTURES: Form of knowledge of the structure and features of the chemical behavior of six- membered heterocyclic compounds with biological activity. Based on their structure, physical and chemical properties to examine the conditions of various processes in the body, with the participation of heterocycles.

3. The questions of: Six-membered heterocycles with one-, two hetero Structure and chemical properties of six- membered heterocyclic Distinguish biologically active isomers of isomers of the compounds studied The value of the studied compounds in the organism

4. 6-Membered heterocycles with one heteroatom O N N N N O  - пиран пиридинхинолин изохинолин акридин

5. Pyran derivatives pyronechromoneflavoneXanthones pyridine picoline lutidine collidine pyridine and its derivatives

6. Getting pyridine:

7. Pyridinium salt

8. Nicotinic acid and its derivatives N COOCH 3 CH 3 H 5 C 2 N C O N C 2 H 5 C 2 H 5 N C O NH 2 N COO H pyridine carbon acid vitamin PP kordiamin smells Chinese jasmine

9. Getting tubazid isonicotinic acid tubazid vanillin ftivazid getting ftivazid

10. Method for obtaining quinoline skraupe:

11. Quinoline derivatives atofan-tsinhofenplazmotsid enteroseptol

12. Atofan - (2-phenyl-4-quinoline carboxylic acid) is used to treat rheumatism and padagry. Plazmotsid - 5-NOK (8-hydroxy-5-nitroquinoline) strong germicide. Enteroseptol-(8-hydroxy-7-iodo-5-chloro-quinoline) is used in the treatment of intestinal inflammation

13. 6-Membered heterocyclic ring with two or more heteroatoms N N N N N NN N N N O H S N H oxazine thiazine pyrazine pyridazine pyrimidine triazine

14. Lacto - lactim tautomers uracil (2,6-dihydroxypyrimidine) thymine (2,6-dihydroxy- 5-methylpyrimidine) cytosine

15. Getting barbituric acid barbituric acid diethyl ether malonate urea

16. BARBITURATES barbital Medinai or Na barbital phenobarbital

17. Phenothiazine and Its Derivatives phenothiazine sedative chlorpromazine

18. Diazepine benzo-1,4-diazepine elenium diazepam

19. Condensed systems heterocyclic compounds purine hypoxanthine xanthineuric acid

20. Lacto - Lacto tautomers N N NH N H O O H N N NH N H O HO N N N N H O O H H lacto xanthine lactam

21. Methylation xanthine N NNH N O O HC 3 CH 3 N NN N O O H CH 3 CH 3 N NN N O O H 3 C CH 3 CH 3 theophylline (1,3-theobromine) tiobromin (3.7-theobromine) caffeine (1,3,7-theobromine

22. Theophylline-found in tea leaves, used as a strong diuretic means. Theobromine, found in beans cook. Diuretic and excites the CNS. Caffeine, found in coffee, especially a lot of tea leaves. has a stimulating effects on the central nervous system and increases efficiency.

23. Aminopurine To include aminopurine adenine (6 - aminopurine) and guanine (2 - amino - 6 - gidroksipurin). They are part of the nucleic acids. adenine guanine