1. Blood

2. Blood Circulation  Powered by the pumping action of the heart  Functions of blood Carries respiratory gases, nutrients, and hormones Helps body regulate temperature  Blood volume Males: 5 – 6 liters Females: 4 – 5 liters

3. Overview: Composition of Blood  Contains cellular and liquid components  A specialized connective tissue Blood cells – formed elements Plasma – fluid portion and fibrinogen  Hematocrit – measure of % RBC Males: 47% ± 5% Females: 42% ± 5%

4. Overview: Composition of Blood Figure 17.1

5. Blood Plasma  Straw-colored, sticky fluid portion of blood  Approximately 90% water  Contains Ions – Na + and Cl - Nutrients – Sugars, amino acids, lipids, wastes, and proteins Three main proteins  Albumin, globulins, and fibrinogen

6. Formed Elements  Blood cells Erythrocytes, leukocytes, and platelets  Staining of blood cells Acidic dye – eosin – stains pink Basic dye – methylene blue – stains blue and purple

7. Figure 17.2b

8. Erythrocytes – Red Blood Cells (RBCs)  Oxygen-transporting cells – 7.5 µm in diameter (diameter of capillary 8 – 10mm)  Most numerous of the formed elements Females: 4.3 – 5.2 million cells/cubic millimeter Males: 5.2 – 5.8 million cells/cubic millimeter  Have no organelles or nuclei

9. Erythrocytes – Red Blood Cells (RBCs)  Hemoglobin – oxygen-carrying protein  Biconcave shape – 30% more surface area Why is this important?  Live 100 – 120 days  Originate in the bone marrow

10. An Erythrocyte Figure 17.3

11. Leukocytes – White Blood Cells (WBCs)  4,800 – 11,000/cubic millimeter  Protect the body from infectious microorganisms  Function outside the bloodstream in loose connective tissue  Diapedesis – circulating leukocytes leave the capillaries

12. Leukocytes – White Blood Cells (WBCs)  Two types of leukocytes Granulocytes Agranulocytes  Never Let Monkeys Eat Bananas

13. Relative Percentages of the Different Types of Leukocytes Figure 17.5

14. Granulocytes  Neutrophils – most numerous WBC Phagocytize and destroy bacteria Nucleus – has two to six lobes Granules pick up acidic and basic stains Figure 17.4a

15.  Eosinophils – compose 1 – 4% of all WBCs Play roles in  Ending allergic reactions, parasitic infections Figure 17.4b

16. Granulocytes  Basophils – about 0.5% of all leukocytes Nucleus – usually two lobes Granules secrete histamines Function in inflammation mediation  Similar in function to mast cells Figure 17.4c

17. Agranulocytes  Lymphocytes – compose 20 – 45% of WBCs The most important cells of the immune system Nucleus – stains dark purple Effective in fighting infectious organisms Act against a specific foreign molecule (antigen) Figure 17.4d

18. Agranulocytes  Two main classes of lymphocyte T cells – attack foreign cells directly B cells – multiply to become plasma cells  Secrete antibodies

19. Agranulocytes  Monocytes – compose 4–8% of WBCs The largest leukocytes Nucleus – kidney shaped Transform into macrophages  Phagocytic cells-travel in body tissues looking for cell debris and bacteria, fungi, etc. Figure 17.4e

20. Platelets  Cell fragments Break off from megakaryocytes  Function in clotting of blood

21. Summary of Formed Elements Table 17.1

22. Blood Cell Formation  Hematopoiesis – process by which blood cells are formed  100 billion new blood cells formed each day

23. Bone Marrow as the Site of Hematopoiesis  Bone marrow – located within all bones Red marrow – actively generates new blood cells  Contains immature erythrocytes  Remains in epiphyses, girdles, and axial skeleton

24. Bone Marrow as the Site of Hematopoiesis Yellow marrow – dormant  Contains many fat cells  Located in the long bones of adults Tissue framework for red marrow  Reticular connective tissue

25. Stages of Differentiation of Blood Cells Figure 17.8 B-lymphocytes are precursors to plasma cells which actually form antibodies

26. Disorders of the Blood  Disorders of erythrocytes Polycythemia  Abnormal excess of erythrocytes Anemia  Erythrocyte levels or hemoglobin concentrations are low

27. Disorders of the Blood  Disorders of erythrocytes (continued) Sickle cell disease  Inherited condition  Results from a defective hemoglobin molecule  Erythrocytes distort into a sickle shape Hemachromatosis  Inherited  Abnormal excess of iron

28. Disorders of the Blood  Disorders of leukocytes Leukemia – a form of cancer  Classified as lymphoblastic or myeloblastic  Disorders of platelets Thrombocytopenia  Abnormally low concentration of platelets

29. The Blood Throughout Life  First blood cells develop with the earliest blood vessels  Mesenchyme cells cluster into blood islands  Late in the second month Liver and spleen take over blood formation  Bone marrow becomes major hematopoietic organ at month 7