1. Shirley M. Tsunoda Liver Transplant, Drug Metabolism/PK Research Interests Investigating the genetic and environmental factors that influence variability in immunosuppressive drug exposure and effect - genetic polymorphisms in drug metabolizing enzymes and transporters - environmental influences such as red wine, grapefruit juice, green tea, food - factors affecting intestinal integrity Understanding how intestinal and hepatic drug metabolizing enzymes and transporters affect bioavailability Understanding the interplay of uptake and efflux transporters and drug metabolizing enzymes in the intestine, liver, and kidney to the efficacy and safety of drugs

2. Core Expertise Clinical research in liver transplant patients Healthy volunteer pharmacokinetic studies Treatment of hepatitis C post-transplant Utilizing pharmacokinetics as a tool to understanding drug exposure, variability, mechanisms of drug-drug interactions Clinical pharmacology of CYP3A and P-gp substrates

3. Proposed Collaborations with SSPPS Faculty Collaborating with faculty who have analytical capability to measure drug and metabolite concentrations Collaborating with faculty with tools and systems to study intestinal and hepatic drug metabolism Pharmacokinetic studies of new compounds in healthy volunteers PK studies in transplant or liver disease patients Clinical pharmacology studies of drug-drug interactions