1. Antioxidants for Health and Sports
Naruemon Leelayuwat, PhD
Department of Physiology,
Faculty of Medicine,
Khon Kaen University, THAILAND
ANSSH: Oct 23, 2015

2. Contents Oxidation-reduction (redox) homeostasis
Oxidative stress vs
diseases and sports
Exogenous and endogenous antioxidants

3. Oxidation-reduction (redox) homeostasis
An oxidation-reduction (redox) reaction is a type of chemical reaction that involves a transfer of electrons between two species
Normal process in our body
Part of the process of muscle repair and regeneration
Immune function .

4. Free radical Non-free radical
Reactive oxygen and nitrogen species (RONS) = ROS and RNS and include both free radical and non-free radical species.
Free radical
Non-free radical
Uric acid
Bilirubin
Superoxide
Hydrogen peroxide
Hydroxyl radicals
Singlet oxygen
Nitric oxide
Peroxynitrite
Hyperchlorite

5. endogenous antioxidant defense system
reactive oxygen and nitrogen species (RONS)
oxidative stress
degenerative and chronic diseases
EXERCISE
eccentric exercise-induced muscle damage (EEIMD)
muscle weakness
delayed onset muscular symptom (DOMS)

6. Oxidative stress vs Diseases

7. Oxidative stress vs Diseases
Görlach et al, Redox Biol; 2015

8. Meng, Yu . Int J Mol Sci. 2010 Apr 12;11(4):1509-26.

9. ROS generation and nutrient availability
Görlach et al, Redox Biol; 2015

10. Oxidative stress vs Exercise (Sports)

11. Sources of Free Radicals During Exercise
Powers and Jackson, 2008

12. Putative redox-sensitive targets in skeletal muscle that can influence force production.
Powers and Jackson 2008

13. Antioxidants Exogenous antioxidant
Endogenous antioxidant; enzymatic, non-enzymatic

14. Exogenous Antioxidants
Fruits, Vegetable, Grains and fish oil
Tea, Coffee, and Chocolate: Rich Sources of Antioxidants
Alcoholic Beverages, liver and egg
Vitamins (vitamin C , E and beta-carotene)
Minerals
Polyphenols  flavonoids  Chrysin

15. Endogenous Antioxidants
Enzymatic; superoxide dismutase, catalase, glutathione peroxidase
Non-enzymatic; vitamins E, alpha lipoic acid (ALA), coenzyme Q10 (CoQ10), glutathione

16. Beneficial effects of antioxidants
Maintain good dental health
Improve nervous system functioning
Protect the liver
Support the immune system
Improve defense power
Reduce obesity
Offer protection against digestive disorder
Support respiratory system
Support kidney function
Improve reproductive function
Have anti-aging effect
Improve quality of sleep
maintain healthy vision
Polyphenols, anthocyanin, was shown to improve endurance and strength performance

17. Hormone influencing antioxidant
growth hormone
Testosterone was able to inhibit in vitro neutrophil prooxidative capability

18. Reasons for the inconsistency
type and concentration of antioxidant compounds,
dose and timing of intervention,
presence of other bioactive compounds
metabolism and biological activities of antioxidants
influence of the factors inherent in the food matrix.

19. Reasons for the inconsistency
dietary intake
training status
exercise protocol
type of muscle-damage marker used

20. Thank You For Your Attention