1. Modification of Neural Circuits with Experience

2. Experience gained… In utero Development Adulthood –By experience, we mean changes in the chemical and external environments –Really hot research area (epigenetics)

3. Changes to Neuron Diversity in Utero Cellular Interaction Model –Neuron diversity reliant on the extent and type of intracellular signaling and genetics –These signaling cascades are sensitive to changes in physiological factors and environmental stressors (anxiety, diet deficiency) –This, in turn, can influence where these neurons migrate to in the cortex, for example

5. Imprinting After Birth

6. Even in humans

7. During adolescence

8. The Importance of Time During Development

9. The Importance of Length During the Critical Period

10. Complementary Changes in Neuronal Architecture

11. Hebbian Theory Neurons that wire together, fire together

12. Somatosensory Cortex of An Amputee

13. Whole System Changes During the Critical Period

14. Epigenetics: Environment + Genetics Diet, anxiety, aggression affects DNA transcription and translation Hugely popular in psychiatric research

17. Optional Reading From my blog “Dormivigilia” – www.dormivigilia.com www.dormivigilia.com Basic review of epigenetic factors and the effects of early-life stress on subsequent development and social relationships