1. E.RICHTER DEPARTMENT OF RHEUMATOLOGY UNIVERSITY OF STELLENBOSCH Immunology

2. Innate and adaptive immunity: cells

3. Innate and adaptive immunity

4. MHC class I and II

5. Complement system

6. Activation of innate immunity

7. PAMP’s and PRR

8. Inflammasomes

10. Jak Stat pathway

11. Cytokines

12. Important cytokines: TNF-alfa

13. Interleukin-6

14. Interleukin-6 and the liver

15. Adaptive immunity: T cell development Positive selection: selection of T cells capable of interacting with MHC molecules. If does not bind to MHC  apoptosis. Develops into either CD4 or CD8 depending on if it binds MHC class I or II. Negative selection: presented with MHC bound to self Ag. If binds too strongly  apoptosis.

16. Requires both signals in order to activate. CD 28 expressed on all CD4 and 50% of CD8 CTLA-4 negative regulator of T cells. Only transiently expressed after T cell activation. Activation of T cell

17. T-helper cells: subsets

18. Adaptive immunity: B cells development

19. B cells: activation

20. Immunoglobulin's

21. Autoimmunity Black arrows=normal events in T cell development Red arrows = circumstances disrupting events  autoimmunity

22. Autoimmunity

23. Autoimmunity: superantigen