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Neuroscience IDP Graduate Students Visit to CCB/LONI: Introduction to Human Brain Mapping Jack Van Horn.

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Presentation on theme: "Neuroscience IDP Graduate Students Visit to CCB/LONI: Introduction to Human Brain Mapping Jack Van Horn."— Presentation transcript:

1 Neuroscience IDP Graduate Students Visit to CCB/LONI: Introduction to Human Brain Mapping Jack Van Horn

2 Phrenology From the work of Franz Josef Gall (1758-1828)

3 Spatio-Temporal Scales Naturally Occurring Lesions PET fMRI Multi-Unit Recording Optical Imaging TMS MEG & ERP Patch Clamp Light Microscopy Single Unit Brain Map Column Layer Neuron Dendrite Synapse 3 2 1 0 -2 -3 -4 -3-201234567 Log Time (sec) Log Size (mm) MillisecondSecondMinuteHourDay Induced Lesions

4

5

6 Mapping Brain Function Assigning quantitative values associated with functionally-related change to spatial locations in the brain.

7 Blood Oxygenation Level Dependence (BOLD) Arteries Veins Capillary Bed Neurons Oxygen Rich Hemoglobin (HbO2) De-oxygenated Hemoglobin More oxygenated HbO2: Less MR signalMore deoxygenated HbO2: More MR signal

8 Calcarine Sulci Fusiform Gyri fMRI Hemodynamic Response 1500ms 500ms 100ms

9 The Localizing of Function Known ReferenceSpatial TransformationAnalysis, Display, & Interpretation

10 3-Planar Views of Activity

11 Mapping Activity on the Surface

12 Example: Retinotopic Mapping from Dougherty et al., Journal of Vision (3),10, 586-598

13 Movement > Rest Rest > Movement (TF Placebo – CF Placebo )>(TF Alcohol – CF Alcohol ) Plac > Alc TF > CF Lobule VI (Med) Lobule VI (Lat) Lobule IV Dentate Crus I Dentate Lobule VIIIA Lobule V E/G F/G CRI/CRII Lobule VI CRI/CRII a. b. c. d. e. f. g. Placebo Alcohol

14 Frontal LeftRight (TF Placebo -CF Placebo ) > (TF Alcohol -CF Alcohol ) LeftRight Parietal Left Placebo Alcohol Right

15 Diffusion Tensor Imaging (DTI) and White Matter Tractography

16 Brain Mapping Summary Mapping and visualization of the brain in vivo is one of the most interesting, profound, beautiful, & fun aspects of neuroscience Mapping and visualization of the brain in vivo is one of the most interesting, profound, beautiful, & fun aspects of neuroscience Rigorous characterization of brain anatomy and function is the essence of brain science at LONI Rigorous characterization of brain anatomy and function is the essence of brain science at LONI

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