1. Logo Authors & Affiliations : Josep L Clua-Espuny (1), Teresa Forcadell-Arenas (1), Rosa Ripolles-Vicente (1), Panisello-Tafalla(1), Antonia González-Henares (1), Lluïsa Queralt-Tomas (1), Carles Anna López-Pablo (2), Iñigo Lechuga-Duran (3), Jorgina Lucas-Noll (1), Miquel Gallofré López (4) on Behalf of Ebrictus Group Investigators 1. (1) Primary care. Institut Català de la Salut. Terres de l’Ebre. Tortosa. España. (2) USR Terres de l’Ebre. IDIAP Jordi Gol-IISPV. Tortosa. (3) Cardiology. Institut Catala de la Salut. Terres de l’Ebre. Tortosa. España. (4) Pla Director de la Malaltia Vascular Cerebral de Catalunya. Dpt de Salut Cataluña, Barcelona. Key words: Stroke. Thrombolysis. Community based study. Mortality. Survival. Results of treatment with fibrinolysis in ischemic stroke. Survival differences by sex. Ebrictus Project.. Rationale A number of large trials have confirmed the benefits of thrombolysis in acute stroke, but there are gender differences in stroke. Methods & Results Ebrictus Project is a study based on a cohort population from incident cases on the first stroke episode (included TIA) from 01/04/2006 to 31/12/2014 participated by Primary care and neurological service referent. Statistical approaches for analyzing survival outcomes and their relation with thrombolysis therapy. A total of 1337 first-ever strokes were included (614 in women). Mean age 74.06±11.9 years (25-90), higher percentage (p 0.004) women than men (54.1%), and significant differences (p <0.001) in the mean age men (72.34±11.9) and females (76.09±11.7) and significantly older (p <0.001) than those in the thrombolysis (68.8±12.0). The mean follow-up was 3.12±2.51 years. The average disease duration is 6.67 years. At 90 days was similar in men and women 8% of deaths and at five years an 44.9%(ICI95% 42.2-47.6). No differences in adjusted mortality rates between sexes (Fig. 1). The incidence rate ratio by sex is 1.003 (IC95%0.86-1.17). Cumulative probability of overall survival is 0.92±0.08 the first month, 0.77±0.01 in the first year and 0.52±0.01 at five The mortality curves among the ischemic with or without thrombolysis are significantly (p <0.003) different (Fig. 2). The Incidence Ratio is 0.57 (CI95% 0.39-0.83). The reduction RRR is 39.8% and ARR 18%, and the NNT 5 to prevent one death. Were identified as protective factors of mortality: the realization of thrombolysis (CI95% 0.37- 0.80 p 0.002), and Barthel ≥ 60 (CI95% 0.81- 0.94 p 0.002) score. 98 (8.6%) patients (48 in women) received thrombolysis. The difference in the number of deaths by gender increases so that at end of period survival is significantly lower in women (Fig. 3) the probability of survival among women was 0.81±0.06 and among men 0.43±0.02 (p 0.012). The factors significantly associated with the survival are the gender (woman OR 1.12 IC95 % 1.05-1.20) and be treated with secondary cardiovascular prevention one year(0.13 IC95 % 0.06-0.28) after stroke. a statistically significant difference (p 0.012) and showed an increased risk in men compared to women IR = 3.2 (IC95% 1.2-8.0). Conclusion The thrombolysis reduces the mortality and disability after first stroke episode, especially among women, and the secondary cardiovascular prevention reduces 7 times the risk of mortality. These results suggest a significant major probability of survival among women that increases progressively beyond 3 months.