1. Haixu Tang School of Informatics
Cell Membrane
Haixu Tang
School of Informatics

2. Membrane Lipids Are Amphipathic Molecules

3. hydrophilic and hydrophobic molecules interact differently with water

4. Packing arrangements of lipid molecules

5. The spontaneous closure of a phospholipid bilayer

6. Phospholipid mobility

7. The other composition of membrane Cholesterol and glycolipids
It inhibits possible phase transitions: (1) decreases the permeability of the bilayer to small water-soluble molecules; (2) prevents the hydrocarbon chains from coming together and crystallizing.

8. Cholesterol

9. Glycolipid

10. Four major phospholipids in mammalian plasma membranes

11. Cell wall

12. Lipid raft

13. The asymmetrical distribution of phospholipids and glycolipids

14. Functions of phospholipids in cell signaling

15. Membrane proteins

16. Membrane attachment of Water soluble proteins

17. Transmembrane polypeptide chain crossing the lipid bilayer

18. Using hydropathy plots to localize potential a-helical membrane-spanning segments

19. b-barrels (occasionally)

20. Solubilizing membrane proteins with a mild detergent

21. Two detergent

22. Reconstituting functional membrane protein system

23. Red cell membrane

24. Preparing red cell ghosts

25. SDS polyacrylamide-gel electrophoresis pattern of the proteins in the human red blood cell membrane

26. Three major ways of proteins association with membranes
Noncovalently Associated with the Cytosolic Side: Spectrin
Extends Through the Red Blood Cell Lipid Bilayer as a Single a Helix: Glycophorin
Multipass Membrane Protein: Band 3 protein

27. Spectrin: cytoskeleton protein

28. Spectrin-based cytoskeleton

29. Glycophorin: single pass membrane proteins

30. Band 3: Anion Transporter
The polypeptide chain (about 930 amino acids long) is thought to extend across the bilayer 12 times.

31. Photosynthetic reaction center

32. The Cell Surface Is Coated with Sugar Residues

33. Carrier proteins and channel proteins

34. A typical ion channel

35. The gating of ion channels

36. Potassium ion gate

37. Passive and active transport

38. Three ways of driving active transport