1. LYMPHATIC SYSTEM WITH A BRIEF INTRODUCTION TO THE IMMUNE SYSTEM

2. LYMPHATIC SYSTEM FUNCTIONS Return Tissue Fluid to Blood (Lost from Blood Capillaries) Defend Against Disease -Production & Differentiation of Lymphocytes -Develop Antibodies Transport Fats from Digestive Organs to Blood

3. LYMPHATIC SYTEM COMPONENTS Lymph -Fluid, Similar to Plasma -Lost from Blood Capillaries -Returned from Interstitial Spaces to Blood by Lymphatic System Lymph Vessels (Lymphatics) -Transport Lymph to Blood (Subclavian Veins)

4. COMPONENTS continued -Begin as Blind-ended Capillaries in Interstitial Spaces -Contain One-way Valves -Cisterna Chyli (from Digestive Organs, pools at L-2, Drains into: -Thoracic Duct (Drains Lower Body + Upper LT. Half into Lt. Subclavian Vein) -Right Lymphatic Duct (Drains Upper Rt. Half into Rt. Subclavian Vein)

5. COMPONENTS continued Lymph Nodes -Located Along Lymph Vessels -Filter Lymph (Lymphocytes) -Occur in Clusters (Cervical, Axillary, Inguinal, etc.) Lymphatic Organs -Tonsils *Along/Around Pharynx *Trap & Remove Pathogens

6. COMPONENTS continued -Thymus *Major Site of T Cell Maturation *Deep to Sternum/Mediastinal -Spleen *Filters Blood (Lymphocytes) *Stores Iron from Recycled RBCs -Bone Marrow *Origin of Immature Lymphocytes -G.A.L.T. *Intestinal Lymphoid Cells

7. CELLS OF THE IMMUNE SYSTEM -WBCs *Chemotaxis (Attracted to Chemicals from Damaged Tissues or Pathogens) *Phagocytes – Cellular Debris & Pathogens  Short Term: Neutrophils  Long Term: Macrophages (“Big Eaters”)

8. CELLS OF THE IMMUNE SYSTEM Lymphocytes Give Rise to: -B Cells (Come from Bone Marrow) *Protect against Bacteria, Foreign Proteins *Can become Plasma Cells (Produce Antibodies) -T Cells (T-lymphocytes) *Mature in thymus *Influence B-cells *Protect against Viruses & Cancer