1. TNIN Tecnologie Non Invasive per le Neuroscienze: Risonanza Magnetica
Federico Giove

2. Mission To develop and exploit NMR approaches for the neurosciences
Visual system, Neuroenergetics
BOLD, MRS, multimodal approaches, neurocurrents
Structural (pathologies)
Visual: noto, si presta aproccio multimodale (MRS), si presta ad una approccio bottom up a fenomeni compelssi, come la percezione

3. BOLD

4. … OR NEURONAL CURRENTS?

6. FUNCTIONAL CONNECTIVITY
MD Fox et al., PNAS 102:9673 (2005)

7. FUNCTIONAL CONNECTIVITY

8. Functional connectivity
GM atrophy
Functional connectivity HS
MCI AD
L -Hippocampus
From PPC seed-region HS
MCI AD
PCC AD HS
MCI
Hippocampus

10. NK Logothetis, Nature 453:869 (2008)

11. ASSESSING THE NEUROMETABOLIC COUPLING
To complement BOLD findings
1H MRS drawbacks
Limited temporal resolution
Low spatial resolution
CREATE STATIONARY “DISENTAGLED” CONDITIONS
Add other modalities

13. 13

14. VISUAL PERCEPTION V1 responds to invisible stimuli
Activation of V1 per se is insufficient for awareness
Sistema delle vie centrali visive – percezione – flickering cromatico
Viswanathan and Freeman, Nat Neurosci 10:1308 (2007)

15. fMRI RESULTS

16. MRS RESULTS 16

17. MRS RESULTS 17

18. Marco Carnì
Antonino M. Cassarà
Mauro Di Nuzzo
Michela Fratini
Girolamo Garreffa,
Marta Moraschi
and Bruno Maraviglia (Fermi Center)
Silvia Mangia (U Minnesota)
Tommaso Gili (U Cardiff)
Silvia Capuani, Giulia Di Pietro, Marco Palombo (U Sapienza)

19. EXTERNAL COLLABORATORS
NEUROPHYSIOLOGY, NEUROSCIENCES:
NK Logothetis, GE Hagberg, Y Murayama (MPI Tuebingen), Emiliano Macaluso (Santa Lucia IRCCS) , Richard G Wise, Silvia De Santis (U Cardiff)
CLINICAL RESEARCH
M Bozzali, G Spalletta (Santa Lucia IRCCS)
MODELLING:
S Vannucci (Columbia), I Simpson (U Penn) , A Carruthers (U Massachusetts), A De Martino, E Marinari (U Sapienza)
PAST COLLABORATORS
M Bianciardi, S Peca, G Giulietti, M Rebuzzi, P Porcari, F Di Salle