2. Annual Technical Review Bruxelles - 4 octobre 2001 Nosologic image : The future graphical user interface J. Underwood, V. Lefournier Unité 438 Grenoble France

3. 1 Select data 4 Check & print 3 Select healthy tissue2 Check peak fitting Next Reset Choose MRS dataChoose MRI data MR image preview Select slice - 1,2,3, etc Selected case : no selection Information about selected MRS data Things to check! MRS & MRI data must be from the same case! Ensure the MRI and MRS data is from the same plane! We suggest you use the middle slice MRI.

4. 1 Select data4 Check & print 3 Select healthy tissue 2 Check peak fitting PreviousNext Reset Selected case : case id Spectrum from currently selected voxel X position slider Healthy Tissue Necrosis Meningioma Oligodendroglioma C.S.F High Grade Ast Low Grade Ast Things to check! Check the automated ‘peak fitting’ (it is not perfect!) for each voxel within the ROI in the image above. To check the voxel click on it - the corresponding spectrum is shown left, the voxel is marked green. Things to check! The spectrum (above) corresponds to the voxel selected (right). Automated identification of spectrum peaks is not perfect - the spectrum may not be in the correct place on the X axis. Use the ‘X position slider’ to move the spectrum and fit again button to try to improve peak identification. Buttons (top left) show ‘typical pattern’ and position for different spectra. Use these to help you re- position badly fitted spectra Fit again MR spectrum from selected voxel showing fitted peaks MR image with MRS voxel grid

5. 1 Select data4 Check & print 3 Select healthy tissue 2 Check peak fitting PreviousNext Reset MR image Selected case : case id Things to do! Use the mouse to select a region of healthy tissue in the image to the right. Position the cursor where you want to start drawing. Press down on the button and drag to draw a selection. Double click to highlight the selected region. If you are happy with your selection click on the ’next’ button. If not click the ‘reset’ button.

6. 1 Select data 4 Check & print 3 Select healthy tissue2 Check peak fitting PreviousPrint Reset MR image & semi-transparent nosologic image overlay (degree of transparency represent certainty?) Selected case : case id Colour Key Classification threshold slider Pie chart showing belonging coefficients for competing classifications at current cursor position Things to do! Use the ‘classification threshold slider’ to produce the image you prefer. See what happens when you move the slider! Inspect competing classification at any point in the image by positioning the cursor over that point; the pie-chart below the image indicates how strongly different classifications are competing. Explanation Some words about what the image shows and what the classification threshold etc… are.