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Relative Contribution of Prepregnancy Overweight and Obesity, Gestational Weight Gain, and IADPSG-Defined Gestational Diabetes Mellitus to Fetal Overgrowth.

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Presentation on theme: "Relative Contribution of Prepregnancy Overweight and Obesity, Gestational Weight Gain, and IADPSG-Defined Gestational Diabetes Mellitus to Fetal Overgrowth."— Presentation transcript:

1 Relative Contribution of Prepregnancy Overweight and Obesity, Gestational Weight Gain, and IADPSG-Defined Gestational Diabetes Mellitus to Fetal Overgrowth The Special Turku Coronary Risk Factor Intervention Project (STRIP) study Featured Article: Olli Oranta, P.H.D., Katja Pahkala, P.H.D., Soile Ruottinen, P.H.D. Harri Niikikoski, M.D., P.H.D., Hanna Lagström, P.H.D., Jorma S.A. Viikari, M.D., P.H.D., Antti Jula, M.D., P.H.D., Britt-Marie Loo, P.H.D., Olli Simell, M.D., P.H.D., Tapani Rönnemaa, M.D., P.H.D., Olli T. Raitakari, M.D., P.H.D. Diabetes Care Volume 36: 2952-2959 October, 2013

2 STUDY OBJECTIVE Low-saturated-fat dietary counseling started in infancy improves insulin sensitivity in healthy children 9 years of age We aimed to evaluate the effect of lifelong dietary counseling on insulin sensitivity in healthy adolescents between 15 and 20 years of age We examined dietary fiber intake and the polyunsaturated fatty acid (PUFA) + monounsaturated (MUFA)-to-saturated fatty acid (SFA) ratio and the association of these dietary factors with homeostasis model of insulin resistance (HOMA-IR) Oranta O. et al. Diabetes Care 2013;36:2952-2959

3 STUDY DESIGN AND METHODS Adolescents participated in the randomized, controlled STRIP study HOMA-IR was assessed annually, as was diet, BMI, pubertal status, serum cotinine concentrations, and physical activity Dietary counseling was given biannually during the follow-up Oranta O. et al. Diabetes Care 2013;36:2952-2959

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5 RESULTS HOMA-IR was lower in the intervention group than in the control group Intervention effect was similar in girls and boys PUFA+MUFA-to-SFA ratio was higher and the dietary fiber (g/MJ) intake was higher in the intervention group compared with the control group There was no association between the PUFA+MUFA-to-SFA ratio and HOMA-IR, whereas dietary fiber intake was associated with HOMA-IR in girls Oranta O. et al. Diabetes Care 2013;36:2952-2959

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8 CONCLUSIONS Dietary counseling initiated in infancy and maintained until 20 years of age was associated with improved insulin sensitivity in adolescents Oranta O. et al. Diabetes Care 2013;36:2952-2959

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