1. What are People Talking About? Medication Discussions on Social Media ICPE August 25 2015 Michele Thomas

2. Authors –Michele Thomas, MBA 2, Bradley Turnbull, MS 3, Jeffery L Painter, BS, JD 1, Rachael L DiSantostefano, PhD 1 and Greg Powell, PharmD, MBA 1. 1 GlaxoSmithKline, RTP, NC, United States; 2 Blue Zone Industries, Inc., Chester Springs, PA, United States and 3 Department of Statistics, North Carolina State University, Raleigh, NC, United States Abstract submitted to International Conference on Pharmacoepidemiology (ICPE)– January 2015 2

3. Conflict of Interest Disclosure The project was funded from the following sources: –GSK The following personal or financial relationships relevant to this presentation existed during the past 12 months/during the conduct of the study: –Employment by commercial entity –Consultancy with GSK

4. Overview for Today –Background and Research Objective –Methodology –Results –Brief look at clustering used to rapidly identify themes in 1000’s of social media posts –Conclusion –Q&A

5. Background: Approach & Objective Contextualization of Real-World Drug Use Through Social Listening –f–f Publically available data is collected from multiple sources (e.g. Facebook, Twitter, Internet forums) System filters out noise, highlights important information, and adds supplemental data (e.g. MedDRA coding, scoring etc.) Users can interactively explore post information using an easy to use interface that helps facilitate the review process 5 OBJECTIVE: Describe discussion topics in social media among individuals communicating about 15 GSK medicines on Twitter and Facebook over 1 year period.

6. Data to Support Research Objective

7. Results –What are patients talking about in social media regarding medications? 7 Note: 45% of ‘Mentions’ were posted by patients; 43% had indication; 71% of Twitter clusters had notable time-based peaks.

8. Post Data & Clustering ProductTextDomainClusterCluster SizeIndication Additional Info Drug Ahave to Someone this stupid Drug A on my nose cause im sick... t(-_-) f - this [link]NACluster 133Y0 Drug Busing Drug B cause my teeth are f****** stupid and hurtNACluster 133Y0 Drug C Can't believe I have another stupid headache! This is like 3 in just over a week. The Drug C didn't help either.... [link]NACluster 133YI Drug CThere is a Drug Y pill at home with my name all over it... ~NACluster 2237NB Drug C@user I have, not working :( I need to go back to drs for some more Drug YNACluster 2237NB Drug C@user I have Drug Y but it sometimes doesn't workNACluster 2237NI Drug CThis Drug C doesn't work. I still have migraineNACluster 3634YI Drug CThis Drug C isn't doing s*** for my migraineNACluster 3634YI Drug CDrug C doing s*** for this migraine. Please let me not have to get up in 5 hrs...NACluster 3634YI Drug DDrug D always has my backNACluster 4530NB Drug DSomeone get my Drug DNACluster 4530N0 Drug DI need a mf Drug DNACluster 4530N0 Drug DThat's given me f****** heartburn. Drug D pleaseNACluster 5155YB Drug DI need some Drug D for this heartburnNACluster 5155Y0 Drug DI really need a Drug D right now. Heartburn.NACluster 5155YB Drug AEven with a f****** Drug A across my nose I can't breatheNACluster 6456NI Drug AGot this Drug A on my nose cause I can't breathe _ _NACluster 6456Y0 Drug A@user I got a Drug A_NACluster 6456N0 Drug EThis Drug E has got me all f***** upNACluster 7419NC Drug EI got a Drug E on and its not doing s***NACluster 7419NI Drug EI need a Drug ENACluster 7419N0 Drug FRT @user: :/ RT @user: I need some Drug FNACluster 8207N0

9. Visualization of Clusters

10. Conclusion –We examined themes among products and changes over time for social media medication posts –More research is needed to understand the utility of theme analysis for safety surveillance. 10